Related Experiment Video

Updated: Jun 24, 2025

Visualizing DNA Damage Repair Proteins in Patient-Derived Ovarian Cancer Organoids via Immunofluorescence Assays
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Visualizing DNA Damage Repair Proteins in Patient-Derived Ovarian Cancer Organoids via Immunofluorescence Assays

Published on: February 24, 2023

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Interplay between altered metabolism and DNA damage and repair in ovarian cancer

Apoorva Uboveja1, Katherine M Aird1

  • 1Department of Pharmacology & Chemical Biology, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|June 14, 2024
PubMed

Insights

Ovarian cancer

Area of Science:

  • Gynecological Oncology
  • Cancer Metabolism
  • DNA Damage and Repair

Background:

  • Ovarian cancer is a leading cause of cancer death globally.
  • It is characterized by DNA repair deficiencies and metabolic reprogramming.
  • These factors contribute to therapeutic resistance.

Purpose of the Study:

  • To review the interplay between metabolic reprogramming and DNA repair in ovarian cancer.
  • To highlight how these pathways influence cancer phenotypes and treatment resistance.
  • To explore potential therapeutic strategies based on this interplay.

Main Methods:

  • Literature review of current research on ovarian cancer metabolism and DNA repair.
  • Analysis of data from other cancers for comparative insights.
  • Discussion of clinical implications for combination therapies.

Main Results:

  • Metabolic rewiring significantly impacts DNA damage and repair mechanisms in ovarian cancer.
  • Specific DNA repair proteins can influence cellular metabolism.
  • Altered DNA repair pathways are a key driver of therapeutic resistance.

Conclusions:

  • The interaction between metabolism and DNA repair is critical in ovarian cancer progression and treatment.
  • Understanding this interplay can guide the development of novel targeted combination therapies.
  • This research has significant clinical implications for improving ovarian cancer treatment outcomes.
Keywords:
PARP inhibitorschemoresistancecisplatinhomologous recombinationmetabolites

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