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Exploring the relationship between creatine supplementation and renal function: insights from Mendelian randomization
Bing Zhou1, Minping Hong1, Liqin Jin2
1Department of Radiology, Jiaxing Hospital of Traditional Chinese Medical, Jiaxing, China.
Renal Failure
|June 14, 2024
Summary
Creatine supplementation does not impact kidney function. This study found no statistical link between creatine levels and renal health indicators, easing concerns for fitness enthusiasts.
Area of Science:
- Sports Science
- Nutritional Biochemistry
- Renal Physiology
Background:
- Creatine is widely used by athletes for performance enhancement.
- Concerns exist regarding creatine's potential effects on kidney health.
- Rigorous scientific data on creatine and renal function is limited.
Purpose of the Study:
- To investigate the association between creatine supplementation and renal function.
- To address concerns within the fitness community about creatine's safety.
Main Methods:
- An online survey collected data on creatine use and renal function concerns from 1129 participants.
- Chi-square tests analyzed survey data for associations.
- Mendelian randomization (MR) techniques using genetic databases assessed the causal link between creatine levels and renal function indicators.
Main Results:
- Chi-square analysis showed no significant association between creatine use and renal function.
- MR analysis, including the inverse variance weighted (IVW) method, found no significant correlation between creatine levels and six renal function indicators (all p > 0.05).
Conclusions:
- This Mendelian randomization study provides strong evidence that creatine levels are not statistically associated with renal function.
- Findings suggest that concerns about creatine negatively impacting kidney health may be unfounded.
- Emphasizes the importance of evidence-based information for dietary supplement choices.
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