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Paraoxonase 1 Activity and Phenotype Distribution in Lumbar Disc Herniation Patients
Utku Adilay1, Nahit Gencer, Kubra Cikrikci
1Balikesir University, Faculty of Medicine, Department of Neurosurgery, Balikesir, Türkiye.
Aim:
To compare the Paraoxonase 1 (PON1) activity and phenotype distribution between lumbar disc herniation (LDH) patients and healthy individuals.
Material And Methods:
This research included 40 LDH patients and 42 healthy individuals. Spectrophotometric assays were performed to determine the serum PON1 and arylesterase activities. The PON1 ratio, which represents the salt-stimulated PON/ arylesterase level, demonstrated a trimodal distribution. This ratio was applied to identify the different phenotypes; QQ, QR, and RR of each subject.
Results:
The LDH patients had lower PON1 activity than the healthy individuals (p < 0.05). LDH patients had a statistically significant QQ phenotype compared to the healthy subjects (p < 0.05).
Conclusion:
LDH patients had statistically lower PON1 activity, suggesting that the low PON1 activity and PON1 QQ phenotype may be a risk factor for LDH occurrence.
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