Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

3.0K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
3.0K
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

1.7K
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.7K
Dementia01:30

Dementia

687
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
687
Gut-Brain Axis01:22

Gut-Brain Axis

222
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such...
222
Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

21
A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial...
21
Dementia l: Introduction01:22

Dementia l: Introduction

35
Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
35

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical Outcomes After Whole and Fascicular Sural Nerve Biopsies: A Retrospective Review.

Plastic surgery (Oakville, Ont.)·2026
Same author

Skeletal muscle candidiasis presenting as degenerative pathology with partial dissolution of myofibers.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026
Same author

Human Cytomegalovirus Associated Neuropathies: A Comprehensive Review From Pathophysiology to Clinical and Therapeutic Considerations.

Journal of the peripheral nervous system : JPNS·2025
Same author

Muscle mitochondrial changes in antisynthetase syndrome and other idiopathic inflammatory myopathies.

Journal of neuropathology and experimental neurology·2025
Same author

Association Between Periventricular and Subcortical White Matter Hyperintensities and Cognition in a Local Population.

The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques·2025
Same author

The Pituitary Immune Environment and Immunotherapy: From Hypophysitis to Pituitary Neuroendocrine Tumors.

Cells·2025

Related Experiment Video

Updated: May 3, 2026

Deciphering and Imaging Pathogenesis and Cording of Mycobacterium abscessus in Zebrafish Embryos
10:38

Deciphering and Imaging Pathogenesis and Cording of Mycobacterium abscessus in Zebrafish Embryos

Published on: September 9, 2015

10.3K

Polymicrobial brain abscesses: A complex condition with diagnostic and therapeutic challenges.

Frances-Claire Eichorn1, Michelle Kameda-Smith2, Crystal Fong3

  • 1Department of Pathology and Molecular Medicine/Diagnostic and Molecular Pathology, McMaster University, Hamilton, Canada.

Journal of Neuropathology and Experimental Neurology
|June 14, 2024
PubMed
Summary

Polymicrobial brain abscesses (PBAs) present complex diagnostic and treatment challenges due to multiple pathogens. Increased awareness and advanced molecular techniques are crucial for prompt and effective management of these life-threatening infections.

Keywords:
abscess stagebrain abscesscoinfectionlesion heterogeneitypathogenpathogenic complexitypolymicrobial

More Related Videos

Analyzing the Permeability of the Blood-Brain Barrier by Microbial Traversal through Microvascular Endothelial Cells
06:26

Analyzing the Permeability of the Blood-Brain Barrier by Microbial Traversal through Microvascular Endothelial Cells

Published on: February 14, 2020

15.5K
Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes
03:53

Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes

Published on: April 19, 2024

515

Related Experiment Videos

Last Updated: May 3, 2026

Deciphering and Imaging Pathogenesis and Cording of Mycobacterium abscessus in Zebrafish Embryos
10:38

Deciphering and Imaging Pathogenesis and Cording of Mycobacterium abscessus in Zebrafish Embryos

Published on: September 9, 2015

10.3K
Analyzing the Permeability of the Blood-Brain Barrier by Microbial Traversal through Microvascular Endothelial Cells
06:26

Analyzing the Permeability of the Blood-Brain Barrier by Microbial Traversal through Microvascular Endothelial Cells

Published on: February 14, 2020

15.5K
Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes
03:53

Growing a Cystic Fibrosis-Relevant Polymicrobial Biofilm to Probe Community Phenotypes

Published on: April 19, 2024

515

Area of Science:

  • Infectious Diseases
  • Neurology
  • Radiology

Background:

  • Brain abscesses (BAs) are serious focal parenchymal infections.
  • Polymicrobial BAs (PBAs) involve coinfections with bacteria, fungi, or parasites, posing unique challenges.

Purpose of the Study:

  • To comprehensively review the prevalence, pathogenesis, clinical, microbiological, histopathological, and radiological features of PBAs.
  • To highlight the diagnostic and therapeutic complexities associated with PBAs.

Main Methods:

  • Review of existing literature on polymicrobial brain abscesses.
  • Analysis of diagnostic challenges, including imaging and pathogen identification.
  • Evaluation of treatment strategies and prognostic factors.

Main Results:

  • PBAs exhibit more complex pathogenesis, pathology, and imaging than monomicrobial BAs.
  • Early imaging may be nonspecific; late-stage heterogeneity correlates with pathogen-induced changes.
  • Molecular analysis is often needed for accurate pathogen identification.

Conclusions:

  • PBAs require greater awareness for timely and appropriate treatment.
  • Multifaceted diagnostic approaches and broad-spectrum antimicrobial therapy are essential.
  • Understanding PBA complexity is key to improving patient outcomes.