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Targeting Hydrogel for Intelligent Recognition and Spatiotemporal Control in Cell-Based Therapeutics.

Weilin Hou1, Wei Mao1,2, Jun Sun1,3

  • 1School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang, Jiangsu, 212003, P. R. China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|June 14, 2024
PubMed
Summary
This summary is machine-generated.

A novel composite hydrogel (PCF-FAMxP) integrates imaging and therapy for smarter cancer treatment. This platform enhances tumor immunogenic cell death (ICD) and immune checkpoint blockade (ICB) therapy, guided by MRI and fluorescence imaging.

Keywords:
hydrogelimmune checkpoint blockadeimmunogenic cell deathmultimodal therapytreatment monitoring

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Cancer Therapy

Background:

  • Traditional cancer theranostics face challenges in efficiency and predictability.
  • Developing integrated platforms for simultaneous imaging and therapy is crucial for improved outcomes.

Purpose of the Study:

  • To develop a smart drug delivery system combining imaging and therapy for enhanced cancer treatment.
  • To create a composite hydrogel (PCF-FAMxP) for spatiotemporally controlled drug release and multimodal imaging.

Main Methods:

  • Fabrication of a thermosensitive hydrogel (polyvinyl alcohol-carboxylic acid hydrogel, PCF) and a multifunctional nanoparticle (Fe3O4@Au/Mn(Zn)-4-carboxyphenyl porphyrin/polydopamine, FAMxP).
  • Integration of PCF and FAMxP to form a composite hydrogel for targeted drug delivery and in situ release.
  • Utilizing magnetic resonance imaging (MRI) and fluorescence imaging (FI) for tumor visualization and treatment guidance.
  • Implementing immunogenic cell death (ICD) and immune checkpoint blockade (ICB) therapy, including photothermal, photodynamic, and chemodynamic approaches.

Main Results:

  • The PCF-FAMxP composite hydrogel demonstrated targeted cell recognition via folate receptors.
  • Near-infrared light triggered thermal dissolution of the hydrogel, enabling slow, in situ release of FAMxP.
  • FAMxP release within tumor cells was pH-dependent, facilitating chemodynamic, photothermal, and photodynamic therapy-induced ICD.
  • Combined therapy significantly enhanced tumor treatment effectiveness when integrated with anti-programmed cell death ligand 1 (ICB).

Conclusions:

  • The developed PCF-FAMxP composite hydrogel offers a promising approach for advanced cancer theranostics.
  • This platform enables cooperative MRI/FI-guided targeted therapeutic pathways, improving treatment efficacy.
  • The simple composition and integrated functionalities represent an updated drug design strategy for complex tumor treatments.