Depression, Cancer, Inflammation, and Endogenous Opioids: Pathogenic Relationships and Therapeutic Options
Jennifer Hancock1, Cristian Sirbu2, Patrick L Kerr3
1Center for Cancer Research, Charleston Area Medical Center, Charleston, WV, USA. jennifer.j.hancock@wv.gov.
Advances in Neurobiology
|June 14, 2024
Summary
The endogenous opioid system, vital for survival behaviors, is pathologically exploited in cancer, leading to depression. Understanding this complex link is crucial for psycho-oncologists treating cancer patients.
Area of Science:
- Neuroscience
- Oncology
- Psychology
Background:
- The endogenous opioid system regulates survival behaviors.
- Cancer and its treatments hijack this system, causing maladaptive responses like inflammation and depression.
- Depression in cancer patients has a unique and complex etiology.
Purpose of the Study:
- To explore the clinical applications of basic scientific findings on the opioid system in cancer.
- To provide psycho-oncologists with knowledge of the biological substrates underlying depression/cancer comorbidity.
Main Methods:
- This chapter builds upon existing knowledge of cancer and endogenous opioids.
- Focuses on translating basic science findings into clinical practice.
Main Results:
- The endogenous opioid system plays a critical role in the development of depression in cancer patients.
- Understanding the neurobiological underpinnings is essential for effective intervention.
Conclusions:
- Psycho-oncologists require a strong grasp of the biological mechanisms linking cancer and depression.
- Clinical applications derived from basic science can improve the management of depression in cancer care.
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