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Analysis of risk factors for fatty liver disease in children with Wilson's disease
Shu-Pei Jia1,2, Mei-Xia Wang2, Zhuang Tao2
1Nanjing University of Chinese Medicine, Jiangsu Province.
Insights
This study identified key risk factors for fatty liver disease (FLD) in children with Wilson's disease, including alanine transaminase (ALT), uric acid, creatinine, fibrinogen (FBG), and laminin. Early identification of FLD in these children is crucial.
Area of Science:
- Hepatology
- Pediatric Gastroenterology
- Metabolic Disorders
Background:
- Wilson's disease often presents with dyslipidemia in children.
- Fatty liver disease (FLD) is a common complication in pediatric Wilson's disease.
- Identifying risk factors for FLD is essential for timely intervention.
Purpose of the Study:
- To investigate the risk factors associated with the development of fatty liver disease (FLD) in children diagnosed with Wilson's disease.
- To identify biochemical predictors for FLD in this pediatric population.
Main Methods:
- Evaluated a comprehensive panel of biochemical markers including liver enzymes (ALT, AST), lipids, uric acid, creatinine, fibrinogen (FBG), and specific fibrosis markers (procollagen III, laminin, hyaluronic acid, type IV collagen).
- Utilized multivariate logistic regression to identify independent risk factors for FLD.
- Employed receiver operating characteristic (ROC) curve analysis to assess the predictive value of individual and combined indicators for FLD.
Main Results:
- Multivariate analysis identified alanine transaminase (ALT), uric acid, fibrinogen (FBG), and laminin as significant independent risk factors for FLD in children with Wilson's disease.
- Creatinine was found to be a protective factor.
- Combined predictive indicators using ROC analysis demonstrated a high predictive value (Area Under Curve = 0.872) for FLD.
Conclusions:
- Alanine transaminase (ALT), uric acid, creatinine, fibrinogen (FBG), and laminin are key risk factors for fatty liver disease in pediatric Wilson's disease.
- The developed joint prediction model is valuable for identifying children with Wilson's disease who are at high risk for FLD.
- This finding aids in early detection and management of FLD in affected children.
Background And Aims:
Many children with Wilson's disease are complicated with dyslipidemia. The aim of this study was to investigate the risk factors for the development of fatty liver disease (FLD) in children with Wilson's disease.
Methods:
We evaluated sex, age, weight, the disease course, treatment course, clinical classification, alanine transaminase (ALT), aspartate transaminase, γ-glutamyl transpeptidase, total biliary acid, triglyceride, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, homocysteine, uric acid, fibrinogen (FBG), creatinine, procollagen III N-terminal propeptide, laminin, hyaluronic acid, type IV collagen, and performed receiver operating characteristic curve analysis to investigate the forecast value of individual biochemical predictors and combined predictive indicators to evaluate FLD in Wilson's disease.
Results:
The multivariate logistic regression analysis revealed that ALT [odds ratio (OR), 1.011; 95% confidence interval (CI), 1.004-1.02; P = 0.006], uric acid (OR, 1.01; 95% CI, 1.002-1.018; P = 0.017), FBG (OR, 3.668; 95% CI, 1.145-13.71; P = 0.037), creatinine (OR, 0.872; 95% CI, 0.81-0.925; P < 0.001), and laminin (OR, 1.01; 95% CI, 1.002-1.018; P = 0.017) acted as independent risk factors in Wilson's disease complicated with FLD. The receiver operating characteristic curves for combined predictive indicators demonstrated an area under the curve values of 0.872, which was found to be a significant predictors for FLD in Wilson's disease.
Conclusions:
We screened out the most important risk factors, namely ALT, uric acid, creatinine, FBG, and laminin for Wilson's disease complicated with FLD. The joint prediction achieved is crucial for identifying children with Wilson's disease complicated with FLD.
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