Related Experiment Video

Updated: Jun 23, 2025

Author Spotlight: RNA FISH for Locating lncRNA-SNHG6 in Osteosarcoma Cells
05:27

Author Spotlight: RNA FISH for Locating lncRNA-SNHG6 in Osteosarcoma Cells

Published on: June 16, 2023

1.4K

Research progress on the role of lncRNA, circular RNA, and microRNA networks in regulating ferroptosis in

Chunlu Yan1, Yinnan Dou2, Ruoliu Xia2

  • 1School of Traditional Chinese and Western Medicine, Gansu University of Chinese Medicine, Lanzhou, Gansu 730000, China.

Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie
|June 14, 2024
PubMed

Insights

Noncoding RNAs (ncRNAs) regulate ferroptosis, a cell death form, in osteosarcoma (OS) development. This review explores ncRNAs

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Death Research

Background:

  • Osteosarcoma (OS) is a primary bone cancer with complex pathogenesis.
  • Ferroptosis, a regulated cell death pathway, is increasingly recognized in cancer.
  • Noncoding RNAs (ncRNAs) are crucial regulators of gene expression with roles in various diseases.

Purpose of the Study:

  • To systematically review the role of ncRNAs in regulating ferroptosis in osteosarcoma (OS).
  • To elucidate the molecular mechanisms underlying ncRNA-mediated ferroptosis in OS pathogenesis.
  • To explore the potential of ncRNAs targeting ferroptosis for OS diagnosis, treatment, and drug resistance.

Main Methods:

  • Literature review of recent studies on ncRNAs, ferroptosis, and osteosarcoma.
  • Analysis of molecular mechanisms by which ncRNAs influence ferroptosis pathways.
  • Synthesis of current knowledge on ncRNA-ferroptosis interplay in OS development.

Main Results:

  • ncRNAs, including microRNAs, long noncoding RNAs, and circular RNAs, significantly impact OS progression by modulating ferroptosis.
  • Specific ncRNAs have been identified as key regulators of ferroptosis-related genes in OS cells.
  • Dysregulation of ncRNAs contributes to OS development, progression, and therapeutic challenges through ferroptosis pathways.

Conclusions:

  • ncRNAs play a critical role in regulating ferroptosis in osteosarcoma.
  • Targeting ncRNAs involved in ferroptosis offers promising avenues for novel OS diagnostics and therapeutics.
  • Further research into ncRNA-ferroptosis interactions is essential for advancing OS clinical management.
Keywords:
FerroptosisMolecular mechanismNcRNAsOsteosarcoma

More Related Videos

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics04:01

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

932
Desthiobiotin-Streptavidin-Affinity Mediated Purification of RNA-Interacting Proteins in Mesothelioma Cells11:11

Desthiobiotin-Streptavidin-Affinity Mediated Purification of RNA-Interacting Proteins in Mesothelioma Cells

Published on: April 25, 2018

8.0K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.6K
Regulation of Expression Occurs at Multiple Steps02:24

Regulation of Expression Occurs at Multiple Steps

Gene expression can be regulated at almost every step from gene to protein. Transcription is the step that is most commonly regulated. This involves the binding of proteins to short regulatory sequences on the DNA. This association can either promote or inhibit the transcription of a gene associated with the respective sequence.
Transcription results in the generation of precursor (pre-mRNA) that consists of both exons and introns, which needs further processing before being translated to a...
22.6K
The Nucleolus02:55

The Nucleolus

The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
8.8K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.8K
Experimental RNAi02:15

Experimental RNAi

RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.1K