Serum 25(OH)D and vitamin K1 levels in patients with severe motor and intellectual disability: A Japanese single-center experience
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View abstract on PubMed
Summary
This summary is machine-generated.Patients with severe motor and intellectual disability (SMID) may have vitamin D and K deficiencies, indicated by higher ucOC levels. Vitamin D supplementation is recommended for this population.
Area Of Science
- Nutritional Science
- Clinical Medicine
- Public Health
Background
- Severe motor and intellectual disability (SMID) can impact nutritional status.
- Understanding vitamin D and K status is crucial for managing health in institutionalized populations.
Purpose Of The Study
- To assess vitamin D and K nutritional insufficiencies in adults with SMID.
- To determine the relationship between vitamin status and bone metabolism markers.
- To guide appropriate vitamin supplementation strategies for SMID patients.
Main Methods
- Prospective observational study of 124 Japanese adults with SMID and 20 controls.
- Measured serum levels of 25-hydroxy vitamin D (25(OH)D) and vitamin K1.
- Assessed serum uncarboxylated osteocalcin (ucOC) as a marker of vitamin K status.
- Compared vitamin intake between tube-fed and orally-fed SMID patients and controls.
Main Results
- SMID patients exhibited higher serum ucOC levels compared to controls.
- Serum 25(OH)D levels were higher in the SMID group overall and in orally-fed vs. tube-fed subgroups.
- Tube-fed SMID patients had lower vitamin D intake, correlating with lower serum 25(OH)D levels.
- Vitamin K intake was low in tube-fed patients, but not correlated with serum vitamin K1 levels.
Conclusions
- Elevated ucOC levels in SMID patients suggest potential vitamin D and K deficiencies.
- Vitamin D supplementation is advised to help reduce ucOC levels in this population.
- Further research into optimal vitamin K supplementation for SMID patients is warranted.
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