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Pan-immune-inflammation value: a new prognostic index in operative laryngeal and pharyngeal carcinomas

  • 0Department of Radiation Oncology, Cheeloo College of Medicine, Qilu Hospital of Shandong University, Shandong University, Jinan, People's Republic of China.
Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico +

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June 14, 2024

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June 14, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Elevated Pan-Immune-Inflammation Value (PIV) indicates a poorer prognosis for patients with laryngeal and pharyngeal tumors. This marker may serve as a valuable tool for assessing patient outcomes in clinical practice.

Area Of Science

  • Oncology
  • Inflammation Markers
  • Tumor Prognosis

Background

  • Laryngeal and pharyngeal tumors pose significant health challenges.
  • Accurate prognostic markers are crucial for effective patient management.
  • The Pan-Immune-Inflammation Value (PIV) is an emerging biomarker.

Purpose Of The Study

  • To evaluate the Pan-Immune-Inflammation Value (PIV) as a prognostic marker.
  • To assess PIV's association with clinicopathological features and survival in laryngeal and pharyngeal tumors.

Main Methods

  • Retrospective analysis of 545 patients with laryngeal and pharyngeal tumors.
  • Determined optimal PIV cutoff and analyzed correlations with clinicopathological features.
  • Utilized survival analysis and Cox regression to assess PIV's impact on overall survival (OS) and disease-free survival (DFS).

Main Results

  • PIV showed significant associations with tumor stage, node stage, postoperative chemotherapy, and vascular thrombosis.
  • Elevated PIV strongly correlated with reduced OS and DFS (p < 0.0001).
  • Multivariate analysis confirmed PIV as an independent prognostic indicator, outperforming other inflammation markers.

Conclusions

  • Elevated PIV is linked to unfavorable prognosis in laryngeal and pharyngeal tumors.
  • PIV demonstrates potential as an adjunctive prognostic indicator.
  • A predictive scoring model was developed with a concordance index of 0.756.

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