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Cancer Survival Analysis

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Novel Prognostic Nomograms For Postoperative Patients With Oral Cavity Squamous Cell Carcinoma In The Central Region Of China.

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Novel Prognostic Nomograms For Postoperative Patients With Oral Cavity Squamous Cell Carcinoma In The Central Region Of China.

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Novel prognostic nomograms for postoperative patients with oral cavity squamous cell carcinoma in the central region

Xue-Lian Xu¹, Jin-Hong Xu², Jia-Qi He³

¹Department of Radiotherapy Oncology, The First Affiliated Hospital of Xinxiang Medical University, 88 Jiankang Road, Xinxiang, 453100, Henan, China.

|June 14, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

This study developed and validated new nomograms to predict overall survival (OS) and disease-free survival (DFS) for oral cavity squamous cell carcinoma (OCSCC) patients in China. These tools aid clinical decision-making for resectable OCSCC.

Keywords:

Dynamic nomogram Oral cavity squamous cell carcinoma Postoperative Prognosis Risk stratification analysis

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Area of Science:

Oncology
Cancer Prognostics
Medical Statistics

Background:

Oral cavity squamous cell carcinoma (OCSCC) is the most prevalent oral malignancy.
Accurate prognostic tools are crucial for managing resectable OCSCC.

Purpose of the Study:

To develop and validate novel prognostic nomograms for resectable OCSCC patients of Chinese descent.
To improve survival prediction and clinical decision-making for OCSCC.

Main Methods:

A cohort of 607 OCSCC patients was divided into training (70%) and validation (30%) sets.
Prognostic factors for overall survival (OS) and disease-free survival (DFS) were identified using univariate and multivariate analyses.
Nomograms were constructed and validated using C-index, calibration curves, NRI, IDI, and DCA.

Main Results:

Established nomograms accurately predict 3- and 5-year OS and DFS in OCSCC patients.
The nomograms demonstrated good discrimination (C-indices ranging from 0.674 to 0.722) and calibration.
Performance was superior to the AJCC staging system, indicating enhanced predictive accuracy.

Conclusions:

The newly developed and validated nomograms offer reliable predictions for OCSCC patient survival.
These nomograms can assist clinicians in treatment planning and patient management.
The study provides valuable prognostic tools for resectable OCSCC within the Chinese population.