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Related Experiment Video

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Associations between deep venous thrombosis and thyroid diseases: a two-sample bidirectional Mendelian randomization

Lifeng Zhang1, Kaibei Li2, Qifan Yang1

  • 1Department of Vascular Surgery, Hospital of Chengdu University of Traditional Chinese Medicine, No. 39, Shierqiao Road, Jinniu District, Chengdu, 610072, Sichuan, People's Republic of China.

European Journal of Medical Research
|June 14, 2024
PubMed
Summary

Autoimmune hyperthyroidism may increase deep venous thrombosis (DVT) risk, according to this Mendelian randomization study. Further research with larger sample sizes is needed for definitive conclusions on thyroid disease and DVT causality.

Keywords:
DatabaseDeep venous thrombosisMendelian randomization analysisThyroid diseases

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Area of Science:

  • Endocrinology and Thrombosis Research

Background:

  • Previous studies on thyroid disease and deep venous thrombosis (DVT) yielded conflicting results.
  • A Mendelian randomization (MR) approach was employed to investigate potential causal links.

Purpose of the Study:

  • To determine if common thyroid diseases are causal factors for deep venous thrombosis (DVT).
  • To utilize a two-sample MR design for robust genetic association analysis.

Main Methods:

  • Employed two-sample Mendelian randomization using genome-wide association study (GWAS) data for thyroid diseases and DVT.
  • Utilized single nucleotide polymorphisms (SNPs) from FinnGen and UK Biobank datasets.
  • Applied inverse variance weighted (IVW), MR-Egger, and weighted median methods, assessing heterogeneity and pleiotropy.

Main Results:

  • Autoimmune hyperthyroidism showed a slight increase in DVT risk (OR=1.0009, p=0.024 via IVW).
  • No significant heterogeneity or horizontal pleiotropy was detected.
  • No causal association was found between other thyroid diseases and DVT.

Conclusions:

  • Autoimmune hyperthyroidism is a potential causal factor for deep venous thrombosis (DVT).
  • Larger sample sizes and further studies are recommended for more conclusive evidence.