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Silicone Bioadhesive with Shear-Stiffening Effect: Rate-Responsive Adhesion Behavior and Wound Dressing Application
Chao Huang1, Qi Wu2, Xixin Li1
1State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, Sichuan, China.
Biomacromolecules
|June 15, 2024
Summary
A new shear-stiffening adhesive (SSA) offers on-demand adhesion for wound healing. This innovative biomaterial simplifies triggering conditions and shows promise for infected wound management.
Area of Science:
- Materials Science
- Biomedical Engineering
- Polymer Chemistry
Background:
- Stimuli-responsive adhesives are crucial for wound healing but often have complex or harmful triggering conditions.
- Existing adhesives can negatively impact the adhesive material and surrounding natural tissues.
Purpose of the Study:
- To develop a novel stimuli-responsive adhesive with simplified, on-demand adhesion capabilities.
- To create a shear-stiffening adhesive (SSA) for improved wound management, particularly for infected wounds.
Main Methods:
- Synthesized a novel poly(diborosiloxane)-based silicone network to create the shear-stiffening adhesive (SSA).
- Incorporated bactericidal factors (PVP-I) into the SSA for application as an infected wound dressing.
Main Results:
- The novel SSA exhibits rate-responsive adhesion behavior, simplifying on-demand activation.
- The SSA demonstrated excellent biocompatibility, long-term antibacterial properties, and accelerated wound healing in infected wounds.
- The developed adhesive dressing effectively promotes the healing of infected wounds.
Conclusions:
- This study presents a new strategy for synthesizing intelligent adhesives with force rate response, simplifying activation mechanisms.
- The shear-stiffening adhesive (SSA) shows significant potential for advanced wound management due to its on-demand adhesion and therapeutic properties.
