Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Case Report: Twenty years of metreleptin therapy in congenital generalized lipodystrophy type 1: the longest reported follow-up to date.

Frontiers in endocrinology·2026
Same author

Lipid clinics worldwide: harmonization and guidance on how to optimally organize and fund. European Atherosclerosis Society consensus statement across 55 countries and more than 500 lipid clinics.

Atherosclerosis·2026
Same author

Exploratory decoding of TMS-EEG: Predicting TEP response to intermittent and continuous theta burst stimulation.

NeuroImage·2026
Same author

Chronic Subthreshold Cortical Stimulation for Paracentral Epilepsy-A Systematic Review.

Neuromodulation : journal of the International Neuromodulation Society·2026
Same author

Environmental influences on anxiety, perceived stress and walking levels in people with epilepsy: A qualitative study using walk-along interviews.

Epilepsy & behavior : E&B·2026
Same author

Transcutaneous vagus nerve stimulation enhances episodic memory across valences and memory stages.

Brain stimulation·2026

Related Experiment Video

Updated: Jun 23, 2025

Transcranial Direct Current Stimulation and Simultaneous Functional Magnetic Resonance Imaging
13:35

Transcranial Direct Current Stimulation and Simultaneous Functional Magnetic Resonance Imaging

Published on: April 27, 2014

21.8K

Investigating the Working Mechanism of Transcranial Direct Current Stimulation.

Emma Lescrauwaet1, Mathieu Sprengers2, Evelien Carrette2

  • 14Brain, Department of Neurology, Reference Center for Refractory Epilepsy, Ghent University Hospital, Ghent, Belgium.

Neuromodulation : Journal of the International Neuromodulation Society
|June 15, 2024
PubMed
Summary

Transcranial direct current stimulation (tDCS) modulates corticospinal excitability, but its mechanism is unclear. Peripheral nerve stimulation appears to contribute to tDCS effects, as shown by reduced excitability changes when scalp nerves are anesthetized.

Keywords:
Mechanism of actionmotor evoked potentialsneuromodulationtranscranial direct current stimulationtranscranial magnetic stimulation

More Related Videos

Electrode Positioning and Montage in Transcranial Direct Current Stimulation
12:00

Electrode Positioning and Montage in Transcranial Direct Current Stimulation

Published on: May 23, 2011

262.6K
Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging
09:33

Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging

Published on: November 15, 2024

1.2K

Related Experiment Videos

Last Updated: Jun 23, 2025

Transcranial Direct Current Stimulation and Simultaneous Functional Magnetic Resonance Imaging
13:35

Transcranial Direct Current Stimulation and Simultaneous Functional Magnetic Resonance Imaging

Published on: April 27, 2014

21.8K
Electrode Positioning and Montage in Transcranial Direct Current Stimulation
12:00

Electrode Positioning and Montage in Transcranial Direct Current Stimulation

Published on: May 23, 2011

262.6K
Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging
09:33

Neuronavigated Focalized Transcranial Direct Current Stimulation Administered During Functional Magnetic Resonance Imaging

Published on: November 15, 2024

1.2K

Area of Science:

  • Neuroscience
  • Neuromodulation

Background:

  • Transcranial direct current stimulation (tDCS) is a neuromodulatory technique.
  • Its precise mechanism of action (MOA) on neuronal activity remains incompletely understood.
  • Investigating tDCS MOA is crucial for optimizing its therapeutic applications.

Purpose of the Study:

  • To elucidate the MOA of tDCS on corticospinal excitability.
  • To determine the contribution of peripheral and cranial nerve stimulation to tDCS effects.
  • To compare tDCS effects with direct current stimulation (DCS) on the cheek.

Main Methods:

  • A randomized cross-over study involving 19 healthy volunteers.
  • Four conditions were tested: tDCS over motor cortex (tDCS-MI), tDCS-MI with topical anesthetic (TA), DCS on the cheek (DCS-C), and sham tDCS.
  • Motor evoked potentials (MEPs) were recorded pre- and post-stimulation; tolerability was assessed via questionnaire.

Main Results:

  • tDCS-MI significantly increased MEP amplitude from 30 to 60 minutes post-stimulation.
  • No significant MEP modulation was observed with tDCS-MI + TA, DCS-C, or sham conditions.
  • Local anesthetic application significantly reduced side effects compared to other conditions.

Conclusions:

  • tDCS significantly modulates corticospinal excitability for up to one hour.
  • Peripheral and/or cranial nerve stimulation may contribute to tDCS effects, not solely direct cortical stimulation.
  • tDCS is generally well-tolerated, especially with local anesthetic application.