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Updated: Jun 23, 2025
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Assessment of Respiratory Function in Conscious Mice by Double-chamber Plethysmography
Published on: July 10, 2018
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Extra-pulmonary control of respiratory defense
Filiz T Korkmaz1, Lee J Quinton1
1Department of Medicine, Division of Immunology and Infectious Disease, UMass Chan Medical School, Worcester, MA 01602, United States.
Cellular Immunology
|June 15, 2024
Summary
Pneumonia remains a major global health threat. This review explores how organs outside the lungs influence pneumonia susceptibility and outcome, revealing potential new therapeutic targets.
Area of Science:
- Immunology
- Infectious Diseases
- Pulmonology
Background:
- Pneumonia is the leading cause of infectious death globally.
- Existing treatments like vaccines and antibiotics are insufficient, necessitating a deeper understanding of host immunity.
- Focus has been on lung-based immunity, with extra-pulmonary influences largely unexplored.
Purpose of the Study:
- To review the role of extra-pulmonary organs in modulating lung immunity and pneumonia outcomes.
- To highlight how signals from organs like the liver, gut, bone marrow, and brain impact pneumonia susceptibility and severity.
- To differentiate protective host responses from detrimental organ injury during pneumonia.
Main Methods:
- Literature review focusing on inter-organ communication in pneumonia.
- Analysis of signaling pathways between extra-pulmonary tissues and the lung.
- Synthesis of current knowledge on host-pathogen interactions beyond the pulmonary system.
Main Results:
- Extra-pulmonary tissues significantly influence local immune responses in the lungs.
- The liver, gut, bone marrow, and brain dispatch signals affecting pneumonia progression.
- Appropriate extra-pulmonary responses can be protective, while aberrant responses contribute to organ injury.
Conclusions:
- Understanding extra-pulmonary contributions to pneumonia is crucial for developing novel therapies.
- Interventions targeting systemic influences may offer new avenues for treating pneumonia and its complications.
- Future research should focus on these extra-pulmonary networks for improved clinical outcomes.
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