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Epigenetic biomarkers in aging and longevity: Current and future application
Mehran Izadi1, Nariman Sadri2, Amirhossein Abdi3
1Department of Infectious and Tropical Diseases, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Synapse Laboratory Diagnostic Technologies Accelerator, Tehran, Iran; Department of Research & Technology, Zeenome Longevity Research Institute, Tehran, Iran.
Life Sciences
|June 15, 2024
Summary
Epigenetic changes are key to aging. Understanding these epigenomic alterations and biomarkers may help reverse aging signs and extend lifespan.
Area of Science:
- Gerontology and Epigenetics: Investigating the molecular underpinnings of aging.
Background:
- Aging is characterized by numerous molecular and cellular changes.
- Epigenetic modifications, including DNA methylation and histone alterations, are conserved hallmarks of aging.
- These epigenomic changes are crucial for gene regulation and cellular identity, interacting with other aging hallmarks like genome instability.
Purpose of the Study:
- To discuss the role of epigenomic mechanisms in the aging process.
- To review recent advancements in epigenetic diagnostic biomarkers for aging.
- To explore the potential of targeting epigenomic modifications to reverse aging and extend lifespan.
Main Methods:
- Review of current scientific literature on epigenetics and aging.
- Analysis of the role of various epigenetic mechanisms (DNA methylation, histone modifications, etc.) in aging.
- Examination of emerging epigenetic biomarkers for age-related diseases.
Main Results:
- Epigenomic alterations are a fundamental aspect of aging, influencing gene expression and cellular function.
- Epigenetic biomarkers show promise for diagnosing and potentially predicting age-related conditions.
- Understanding locus-specific epigenomic modifications is key to developing interventions.
Conclusions:
- Epigenetic mechanisms are central to aging and age-related diseases.
- Epigenetic diagnostic biomarkers offer a pathway for targeted interventions.
- Further research into epigenomics is crucial for extending healthspan and lifespan.
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