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Elevated urinary dolichol levels in chronic alcoholics.

R K Pullarkat, S Raguthu

    Alcoholism, Clinical and Experimental Research
    |January 1, 1985
    PubMed
    Summary
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    Chronic alcoholics exhibit significantly elevated urinary dolichol levels. Abstinence from alcohol gradually normalizes these dolichol (long chain 2,3-dihydropolyprenol) levels, suggesting a link between alcohol consumption and dolichol metabolism.

    Area of Science:

    • Biochemistry
    • Clinical Chemistry
    • Toxicology

    Background:

    • Dolichols are long-chain polyprenols involved in glycoprotein synthesis.
    • Altered dolichol metabolism has been implicated in various disease states.
    • Chronic alcohol abuse is associated with numerous metabolic disturbances.

    Purpose of the Study:

    • To investigate urinary dolichol levels in chronic alcoholics compared to healthy individuals.
    • To determine the effect of alcohol abstinence on urinary dolichol concentrations.

    Main Methods:

    • Urinary dolichol levels were quantified using high-performance liquid chromatography (HPLC).
    • A cohort of 23 chronic alcoholics and 15 normal subjects was analyzed.
    • Follow-up measurements were taken after a period of alcohol cessation.

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    Main Results:

    • Normal subjects had mean urinary dolichol levels of 4.7 ± 2.8 ng/ml.
    • Chronic alcoholics showed markedly increased levels, averaging 61.1 ± 44.6 ng/ml.
    • Following alcohol cessation for several weeks, urinary dolichol levels progressively returned to normal ranges.

    Conclusions:

    • Chronic alcohol consumption leads to a significant elevation in urinary dolichol levels.
    • Urinary dolichol levels serve as a potential biomarker for chronic alcohol abuse.
    • Alcohol abstinence is associated with the normalization of dolichol metabolism.