Related Experiment Video

Updated: Jun 23, 2025

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones
11:36

In Vitro Ubiquitination and Deubiquitination Assays of Nucleosomal Histones

Published on: July 25, 2019

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The Roles of Cytoplasmic Polyadenylation Element Binding Protein 1 in Tumorigenesis

JiaYi Li1,2,3, Yinxin Wu1,2,3, Dingyin Zhang1,2,3

  • 1Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University.

Mini Reviews in Medicinal Chemistry
|June 16, 2024
PubMed
Abstract

Insights

The cytoplasmic polyadenylation element-binding protein 1 (CPEB1) acts as both a tumor suppressor and promoter across various cancers. Its dual role highlights its potential as a prognostic indicator and therapeutic target in oncology.

Area of Science:

  • Molecular biology
  • Cancer research
  • Biochemistry

Background:

  • CPEB1, a polyadenylation binding protein, influences mRNA and protein expression by binding to the Cytoplasmic Polyadenylation Element (CPE).
  • Abnormal CPEB1 expression is linked to tumorigenesis across multiple cancer types.
  • This review explores CPEB1's multifaceted roles in cancer development.

Purpose of the Study:

  • To review and summarize the functions and mechanisms of CPEB1 in various cancers.
  • To dissect CPEB1's impact on the initiation and progression of specific malignancies.
  • To suggest future therapeutic directions involving CPEB1.

Main Methods:

  • Systematic review of 95 eligible articles.
  • Analysis focused on CPEB1's association with glioblastoma, breast cancer, hepatocellular carcinoma, gastric cancer, colorectal cancer, non-small cell lung cancer, prostate cancer, and melanoma.
  • Evaluation of research quality and strength of association with CPEB1.

Main Results:

  • CPEB1 functions as a tumor suppressor in breast, endometrial, hepatocellular, non-small cell lung, prostate cancers, and melanoma.
  • In glioblastoma, gastric, and colorectal cancers, CPEB1 exhibits dual roles, promoting or inhibiting tumorigenesis.
  • CPEB1's expression patterns vary significantly across different cancer types.

Conclusions:

  • CPEB1 shows potential as a therapeutic target and prognostic biomarker in oncology.
  • Its functions in apoptosis, proliferation, migration, invasion, stemness, drug resistance, and ferroptosis are relevant to cancer.
  • CPEB1's dynamic detection index could aid in cancer management.
Keywords:
3’UTRCPEB1RNA-binding domain.cancersmRNAsmechanismsignalingtumorigenesis

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