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  11. Half Of Most Frequently Mutated Genes In Breast Cancer Are Expressed Differentially Between Premenopausal And Postmenopausal Breast Cancer Patients.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Half Of Most Frequently Mutated Genes In Breast Cancer Are Expressed Differentially Between Premenopausal And Postmenopausal Breast Cancer Patients.

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Half of most frequently mutated genes in breast cancer are expressed differentially between premenopausal and postmenopausal breast cancer patients.

Caglar Berkel1, Ercan Cacan1

  • 1Department of Molecular Biology and Genetics, Tokat Gaziosmanpasa University, Tokat, Türkiye.

Cancer Genetics
|June 16, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Menopause status impacts frequently mutated breast cancer genes. Gene expression differs between premenopausal and postmenopausal women, often correlating with estrogen or progesterone receptor status.

Keywords:
Breast cancerEstrogen receptorFAT1HER2

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Area of Science:

  • Oncology
  • Genetics
  • Endocrinology

Background:

  • Breast cancer incidence and molecular profiles vary significantly between premenopausal and postmenopausal women.
  • Postmenopausal breast cancer is over 10 times more common than premenopausal breast cancer.

Purpose of the Study:

  • To investigate how menopause status influences the expression of frequently mutated genes in breast cancer.
  • To explore the relationship between menopause status, gene expression, and hormone receptor (estrogen receptor [ER], progesterone receptor [PR]) and HER2 (human epidermal growth factor receptor 2) status.

Main Methods:

  • Analysis of gene expression data from premenopausal and postmenopausal breast cancer patients.
  • Comparison of expression levels for 20 frequently mutated genes based on menopausal status.
Hormone receptor
Menopause
PIK3CA
Postmenopausal women
Postmenopause
Progesterone receptor
RUNX1
  • Correlation analysis of gene expression with ER, PR, and HER2 status.

    • Main Results:

    • Expression of 10 key mutated genes (including PIK3CA, CDH1, PTEN, FAT1, RUNX1) was higher in premenopausal women.
    • RUNX1 and FAT1 showed the most significant expression differences related to menopause status.
    • Most of these genes exhibited ER or PR status-dependent expression, but not HER2 status-dependent expression.

    Conclusions:

    • Menopause status is a significant factor influencing the expression of frequently mutated genes in breast cancer.
    • The observed differences in gene expression between pre- and postmenopausal women are often linked to ER and PR status.