Related Experiment Video
Updated: Jun 7, 2026
Intrastriatal Injection of Autologous Blood or Clostridial Collagenase as Murine Models of Intracerebral Hemorrhage
Published on: July 3, 2014
Influence of matrix metalloproteinase 9 variant rs17576 on ischemic stroke risk and severity in acute coronary
Neda M Bogari1, Hind Mansour Naffadi1, Ahmad O Babalghith1
1Department of Medical Genetics, Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Background:
Ischemic injury is a common mechanism in both ischemic stroke (IS) and acute coronary syndrome (ACS). Matrix metalloproteinase 9 (MMP-9), an endopeptidase that degrades extracellular matrix, is important in the pathogenesis of IS. The purpose of this study is to evaluate the association between the SNP rs17576 in MMP-9 gene with (1) the risk and severity of acute ischemic stroke in Saudi Arab individuals with recent acute coronary syndrome, and (2) the risk of acute coronary syndrome in Saudi Arab individuals without ischemic stroke.
Methods:
A case control study of 200 IS patients, 520 ACS patients (without IS), and 500 aged-matched healthy controls were genotyped to detect the MMP-9 polymorphism rs17156.
Results:
Our study demonstrated a non-significant difference in the genotype and allele frequencies of the MMP9 rs17576 polymorphism between the patients with IS and patients with ACS without IS (P = 0.31 for the GA genotype, 0.25 for the AA genotype and P = 0.20 for the A allele). AA genotype was found to be statistically significant between IS and control groups; [OR=1.84, 95 % CI (1.08-3.14), p =0.015]. A allele showed a significant difference between the two groups [OR=1.28, 95 % CI (1.00-1.64), p =0.028]. By comparing ACS without IS and controls, AA genotype was significant [OR=1.46, 95 % CI (1.01-2.12), p =0.029]. Stratification by NIHSS score revealed higher mortality and early neurologic deterioration in IS patients with NIHSS score ≥ 16 (p < 0.001, 0.044 respectively).
Conclusion:
We deduced the lack of association either with allele or genotype frequencies (p>0.05) between the IS cases and the cases of ACS without IS. In contrast there was a significant association of mutant genotype AA between either the IS group or ACS (without IS) group, and the control group. In addition, different rs17576 genotypes were not associated with raised mortality or a tendency to develop early neurologic deterioration.
Insights
The MMP-9 rs17576 polymorphism
Area of Science:
- Cardiovascular Research
- Neurology
- Genetics
Background:
- Ischemic injury underlies both ischemic stroke (IS) and acute coronary syndrome (ACS).
- Matrix metalloproteinase 9 (MMP-9) plays a role in IS pathogenesis.
- The MMP-9 gene's rs17576 single nucleotide polymorphism (SNP) is investigated.
Purpose of the Study:
- To assess the association of the MMP-9 rs17576 SNP with IS risk in Saudi Arab ACS patients.
- To evaluate the link between the MMP-9 rs17576 SNP and ACS risk in individuals without IS.
Main Methods:
- A case-control study included 200 IS patients, 520 ACS patients (no IS), and 500 controls.
- Genotyping was performed to detect the MMP-9 rs17576 polymorphism.
Main Results:
- No significant difference in MMP-9 rs17576 genotype/allele frequencies between IS and ACS (no IS) groups.
- The AA genotype was significantly associated with IS risk compared to controls (OR=1.84).
- The AA genotype was also significant for ACS (no IS) risk versus controls (OR=1.46).
Conclusions:
- The MMP-9 rs17576 polymorphism showed no association between IS and ACS (no IS) groups.
- A significant association was found between the mutant AA genotype and both IS and ACS (no IS) groups compared to controls.
- rs17576 genotypes were not linked to increased mortality or early neurological deterioration.
Related Concept Videos
01:29Pharmacogenetic Phenotypes: Alterations in Pharmacokinetics, Drug Targets and Biologic Milieu
01:30Acute Coronary Syndrome I: Introduction
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
01:30Acute Coronary Syndrome III: Diagnostic Studies