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3D printing of fish-scale derived hydroxyapatite/chitosan/PCL scaffold for bone tissue engineering
Zhihua Liu1, Jinnan Shi1, Lingying Chen1
1Department of Spinal Surgery, The Second Clinical Medical College of Fujian Medical University, The Second Affiliated Hospital of Fujian Medical University, Fujian 362000, China.
International Journal of Biological Macromolecules
|June 16, 2024
Summary
This study developed novel 3D-printed hydroxyapatite/chitosan/polycaprolactone scaffolds for bone repair. The optimized scaffolds show excellent antimicrobial properties, superhydrophilicity, and promote bone tissue regeneration.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Tissue Engineering
Background:
- Bone defect treatment remains a significant clinical challenge.
- Bone tissue engineering offers innovative solutions for bone repair.
- Development of advanced bone grafting materials is crucial.
Purpose of the Study:
- To prepare and characterize a novel hydroxyapatite (HA) material.
- To fabricate and evaluate 3D-printed HA/chitosan (CS)/polycaprolactone (PCL) scaffolds for bone tissue repair.
- To assess the antimicrobial, physical, and biological properties of the developed scaffolds.
Main Methods:
- Preparation and characterization of a novel HA material.
- Fabrication of HA/CS/PCL scaffolds using 3D printing technology.
- Compositional analysis (XRD, FT-IR), surface morphology observation, antimicrobial assays, water contact angle measurements, and in vitro/in vivo biological evaluations.
Main Results:
- Successful preparation and characterization of a novel HA material.
- 3D-printed scaffolds with confirmed composition and tunable surface morphology based on HA content.
- Scaffolds with 30%HA + 5%CS + PCL exhibited significant antimicrobial activity.
- Demonstrated superhydrophilicity, excellent bioactivity, and promotion of tissue regeneration in vitro and in vivo.
Conclusions:
- The developed 3D-printed HA/CS/PCL scaffolds show promising potential for bone tissue repair.
- The optimized scaffold composition offers a combination of antimicrobial properties, favorable surface characteristics, and enhanced bioactivity.
- These findings provide new avenues for clinical applications in bone regeneration.
