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[Intrathecal baclofen therapy: a 30-year experience]
1Privolzhsky Research Medical University, Nizhny Novgorod, Russia.
Zhurnal Voprosy Neirokhirurgii Imeni N. N. Burdenko
|June 17, 2024
Summary
Intrathecal baclofen infusion treats severe spasticity when oral medications fail. Careful management minimizes side effects, improving quality of life for mobility-impaired individuals.
Area of Science:
- Neurology
- Pharmacology
Background:
- Intrathecal baclofen infusion, established in 1984, offers a niche treatment for drug-resistant muscle spasticity.
- Despite proven benefits for daily activity and quality of life, its routine use is limited by adverse event analysis.
Purpose of the Study:
- To review and systematize data on intrathecal baclofen therapy over 30 years.
- To consolidate information on indications, patient selection, implantation, management, and outcomes.
Main Methods:
- A comprehensive review of national and international literature was conducted.
Main Results:
- Intrathecal baclofen therapy is effective for severe spasticity unresponsive to oral muscle relaxants.
- Benefits include improvements in articulation, chewing, and spastic pain management.
- Correct dosing and catheter management are crucial for reducing side effects and improving tolerance.
Conclusions:
- Prolonged intrathecal baclofen infusion is a promising long-term treatment for severe spasticity impacting quality of life and self-care.
- The therapy is indicated when oral muscle relaxants are contraindicated or ineffective.
- Optimizing drug dosage and addressing catheter-related issues enhance treatment efficacy and patient tolerance.
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