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Correlation between cigarette smoking and alcohol consumption and Rosacea: A two-sample Mendelian randomization study
1Department of Otorhinolaryngology, Central Hospital Affiliated to Chongqing University of Technology, Chongqing, China.
Summary
Investigating smoking and alcohol
Area of Science:
- Genetics and Epidemiology
- Dermatology
- Public Health
Background:
- The relationship between smoking, alcohol consumption, and rosacea remains debated.
- Mendelian randomization (MR) is utilized to explore causal links.
- Insights are sought for rosacea prevention and early treatment.
Purpose of the Study:
- To investigate the causal association between cigarette smoking, alcohol consumption, and rosacea.
- To provide evidence-based insights for rosacea management.
Main Methods:
- Utilized two-sample Mendelian randomization (MR) analysis.
- Employed summary datasets from genome-wide association studies (GWAS) for smoking and alcohol consumption, and rosacea.
- Applied various MR methods including Inverse Variance Weighting (IVW) as the primary approach.
Main Results:
- A significant negative association was found between cigarettes smoked per day and rosacea.
- A significant positive correlation was observed between previous smoking status and rosacea.
- No significant associations were detected for current smoking status or alcohol consumption with rosacea.
Conclusions:
- Cigarette smoking cessation may increase rosacea risk, while daily cigarette consumption is linked to reduced incidence.
- Alcohol consumption was not found to be a significant risk factor for rosacea.
- Findings offer a nuanced understanding of lifestyle factors in rosacea development, aiding prevention and intervention strategies.
