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Odontogenic Maxillary Sinusitis Microbiology Compared With Chronic Rhinosinusitis: A Meta-Analysis
Chang Lu1, Yue Zhao1, Yicheng Qin1
1Department of Stomatology, Beijing TongRen Hospital, Capital Medical University, Beijing, China.
American Journal of Rhinology & Allergy
|June 17, 2024
Summary
Odontogenic maxillary sinusitis (OMS) shows higher prevalence of Fusobacterium compared to chronic rhinosinusitis (CRS). Staphylococcus aureus is more common in CRS, aiding in differential diagnosis and treatment strategies for these sinusitis subtypes.
Area of Science:
- Otorhinolaryngology
- Microbiology
- Medical Diagnostics
Background:
- Sinusitis subtypes present distinct clinical characteristics and prognoses due to varying pathogens.
- Odontogenic maxillary sinusitis (OMS) is typically unilateral, differing from bilateral chronic rhinosinusitis (CRS).
- Previous microbiological comparisons between OMS and CRS have been limited and methodologically biased.
Purpose of the Study:
- To conduct a comprehensive meta-analysis comparing the microbiology of OMS and CRS.
- To provide evidence for differentiating OMS and CRS based on their microbial profiles.
- To identify key bacterial differences that may explain distinct pathologies and inform diagnostic/therapeutic strategies.
Main Methods:
- Systematic literature search of PubMed and CNKI databases up to July 2023.
- Meta-analysis using a random-effects model to estimate pooled prevalence of bacterial species/genera.
- Inclusion of 17 studies encompassing OMS, CRS, and normal sinus samples.
Main Results:
- Analysis included 191 OMS, 610 CRS, and 92 normal sinus samples.
- Fusobacterium showed a significantly higher prevalence in OMS compared to CRS.
- Staphylococcus aureus was found to be more prevalent in CRS than in OMS.
Conclusions:
- Fusobacterium is a key differentiator, being significantly more prevalent in OMS than CRS.
- Staphylococcus aureus prevalence is higher in CRS, suggesting distinct microbial etiologies.
- Microbial profile differences support novel diagnostic and therapeutic approaches for OMS and CRS.
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