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Prognostic value of NOB1 expression levels in various cancers: a systematic review and meta-analysis
Yi Zhang1, Zheng Li1, Xi Chen1
1Department of Radiation Oncology, Division of Thoracic Oncology,Cancer Center, West China Hospital, Sichuan University, Chengdu, 610041, P.R. China.
Abstract:
Aim: This study evaluates the prognostic significance of NOB1 expression levels in various cancers.Patients & methods: Studies examining NOB1 expression in cancer, encompassing data from 1694 patients across 14 studies, were analyzed for overall survival (OS) and progression-free survival (PFS) using hazard ratios (HRs) and 95% CIs, and for clinicopathological parameters using relative risks (RRs).Results: High NOB1 expression correlated with shorter OS (HR: 2.12, 95% CI: 1.82-2.48) and PFS (HR: 2.23, 95% CI: 1.62-3.07) and was associated with adverse tumor characteristics such as stage and metastasis.Conclusion: Elevated NOB1 expression in various tumors signifies a poor prognosis, serving as a predictive marker for malignancy outcomes.PROSPERO Register Number: CRD42023394051.

