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Gut microbiota and functional dyspepsia: a two-sample Mendelian randomization study.

Yichuan Xv1, Jiaxu Chen2, Jiang Lin1

  • 1Department of Gastroenterology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Frontiers in Microbiology
|June 17, 2024
PubMed
Summary

This study identifies specific gut bacteria linked to functional dyspepsia (FD). Certain Clostridium and Ruminiclostridium species increase FD risk, while Lachnospiraceae may offer protection, guiding future gut microbiota therapies.

Keywords:
Mendelian randomizationcausal effectfunctional dyspepsiafunctional gastrointestinal disordersgut microbiota

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Area of Science:

  • Gastroenterology and Microbiology
  • Human Gut Microbiome Research
  • Genetic Epidemiology

Background:

  • Gut microbiota (GM) alterations are recognized in functional dyspepsia (FD).
  • Specific GM taxa contributing to FD pathogenesis remain largely unidentified.
  • Understanding these links is crucial for developing targeted therapies.

Purpose of the Study:

  • To investigate the causal relationships between specific gut microbiota taxa and functional dyspepsia.
  • To identify potential gut microbiota-related genes associated with FD risk.
  • To provide a basis for future gut microbiota-targeted therapeutic strategies for FD.

Main Methods:

  • Employed a two-sample Mendelian randomization analysis using large-scale GWAS data.
  • Utilized the inverse-variance weighted (IVW) method for primary analysis.
  • Conducted sensitivity analyses to assess heterogeneity and pleiotropy; mapped causal taxa to genes for further analysis.

Main Results:

  • The genera *Clostridium innocuum group* (OR: 1.12) and *Ruminiclostridium 9* (OR: 1.27) showed a positive association with increased FD risk.
  • The genus *Lachnospiraceae FCS020 group* (OR: 0.84) demonstrated a potential protective effect against FD.
  • The gene RSRC1 was significantly associated with an elevated risk of FD (OR: 1.13); sensitivity analyses confirmed robustness.

Conclusions:

  • This research provides evidence for distinct causal effects of specific gut microbiota taxa on FD.
  • Identified specific bacterial genera and a gene (RSRC1) linked to FD risk.
  • Offers a potential biological mechanism and theoretical foundation for future microbiotherapy interventions in FD.