Related Experiment Video
Updated: Jun 23, 2025
07:52
A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
Published on: November 7, 2017
20.5K
The Combination of Hyperuricemia and Elevated High-Sensitivity C-Reactive Protein Increased the Risk of Cardiac
Na Li1, Liufu Cui1, Gary Tse2,3
1Department of Rheumatology and Immunology, Kailuan General Hospital, Tangshan, Hebei Province, People's Republic of China.
Journal of Inflammation Research
|June 17, 2024
Summary
High uric acid (HUA) and high-sensitivity C-reactive protein (hs-CRP) significantly increase cardiac conduction block (CCB) risk, particularly atrioventricular block. hs-CRP partially mediates the link between uric acid and CCB development.
Area of Science:
- Cardiology
- Biochemistry
- Epidemiology
Background:
- Hyperuricemia (HUA) and elevated high-sensitivity C-reactive protein (hs-CRP) are independently associated with cardiovascular disease.
- The combined impact of HUA and low-grade inflammation on cardiac conduction block (CCB) risk is not well understood.
- Investigating the potential mediating role of hs-CRP in the relationship between uric acid (UA) and CCB is crucial for understanding disease mechanisms.
Purpose of the Study:
- To examine the association between combined hyperuricemia and elevated hs-CRP levels with the incidence of cardiac conduction block (CCB).
- To determine if hs-CRP mediates the effect of uric acid on the risk of developing CCB.
Main Methods:
- A prospective cohort study of 81,896 individuals without baseline CCB from the Kailuan cohort.
- Participants were stratified into four groups based on HUA and hs-CRP levels (low-grade inflammation defined as hs-CRP > 3 mg/L).
- Cox regression and mediation analyses were used to assess CCB risk and the mediating role of hs-CRP.
Main Results:
- The combination of HUA and low-grade inflammation was associated with increased risks of CCB (HR: 1.56), atrioventricular block (AVB) (HR: 1.88), and right bundle branch block (HR: 1.47) compared to the low UA/low CRP group.
- In individuals with HUA, the overall risk of CCB increased by 14.0% compared to those without HUA.
- Mediation analysis indicated that 10.3% of the increased CCB risk in the HUA group was attributable to hs-CRP.
Conclusions:
- Concomitant hyperuricemia and elevated hs-CRP significantly elevate the risk of cardiac conduction block, with a notable impact on atrioventricular block.
- The association between uric acid levels and CCB risk is partly explained by the mediating effect of hs-CRP.
- These findings highlight the importance of managing both HUA and inflammation for cardiovascular protection.
More Related Videos
18:11A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis
Published on: December 28, 2012
24.3K
09:36Dual-Dye Optical Mapping of Hearts from RyR2R2474S Knock-In Mice of Catecholaminergic Polymorphic Ventricular Tachycardia
Published on: December 22, 2023
1.2K
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
77
Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
77
01:26Imbalances in Cardiac Output
1.4K
The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.4K
01:28Mechanism of Cardiac Arrhythmias
910
Arrhythmias are irregular heart rhythms occurring when the heart's electrical impulses become abnormal. These disturbances can lead to various symptoms, depending on their severity and the underlying cause. Some common factors contributing to arrhythmias include hypoxia, ischemia, electrolyte imbalances, excessive catecholamine exposure, drug toxicity, and muscle overstretching. Arrhythmias can be classified into two main types based on the rate and site of origin of abnormal heart rhythms.
910
01:28Disturbances in Heart Rhythm
933
Arrhythmia or dysrhythmia refers to an abnormal heart rhythm caused by a defect in the heart's conduction system. It can cause the heart to beat irregularly, too quickly, or too slowly, leading to symptoms like chest pain, shortness of breath, and fainting. Factors such as stress, caffeine, alcohol, nicotine, cocaine, certain drugs, congenital defects, diseases, and electrolyte abnormalities can trigger arrhythmias.
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
Arrhythmias are categorized by their speed, rhythm, and origin. A slow...
933
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
420
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
420
01:17Increased pulse rate
652
Tachycardia is a condition marked by an abnormally fast or irregular heart rate, surpassing the typical resting rate. In adults, tachycardia is characterized by a pulse rate ranging from 100 to 180 beats per minute. The increased heart rate can result in inadequate blood flow to various body parts, ultimately diminishing the oxygen supply to organs and tissues.
Many factors can elevate the risk of developing tachycardia. These include advanced age, a family history of arrhythmias, and an...
Many factors can elevate the risk of developing tachycardia. These include advanced age, a family history of arrhythmias, and an...
652