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Advantageous properties of a new fungicide, isofetamid

Shuko Nishimi1, Yuzuka Abe1, Nanami Kuwahara2

  • 1Biosciences Business Headquarters, Ishihara Sangyo Kaisha, Ltd.

Journal of Pesticide Science
|June 17, 2024
PubMed

Insights

Isofetamid demonstrates potent fungicidal activity against common plant pathogens like Botrytis cinerea by inhibiting succinate dehydrogenase. This new fungicide is effective even against strains resistant to existing treatments.

Area of Science:

  • Agricultural Science
  • Mycology
  • Biochemistry

Background:

  • Botrytis cinerea causes significant crop losses globally.
  • Fungal resistance to existing fungicides necessitates the development of new agents.
  • Understanding fungicide mode of action is crucial for effective disease management.

Purpose of the Study:

  • To evaluate the fungicidal properties of isofetamid against Botrytis cinerea.
  • To determine the antifungal spectrum and mode of action of isofetamid.
  • To assess isofetamid's efficacy against fungicide-resistant B. cinerea isolates.

Main Methods:

  • Mycelial growth inhibition assays were performed.
  • Respiratory enzyme assays using isolated mitochondria were conducted.
  • Inhibition of fungal infection processes was observed.

Main Results:

  • Isofetamid showed high fungicidal activity against ascomycetes, including Botrytis cinerea.
  • The fungicide inhibited succinate dehydrogenase activity in B. cinerea and other ascomycetes.
  • Isofetamid effectively inhibited multiple stages of the B. cinerea infection process.
  • Efficacy was demonstrated against B. cinerea isolates resistant to conventional fungicides.

Conclusions:

  • Isofetamid is a promising fungicide with a specific mode of action targeting succinate dehydrogenase.
  • Its effectiveness against resistant strains offers a valuable tool for managing Botrytis cinerea.
  • Further research into isofetamid's application in agriculture is warranted.
Keywords:
fungicidal propertiesfungicidal spectrumisofetamidmode of action

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