Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Autoimmune Disorders01:29

Autoimmune Disorders

415
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
415
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

84
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
84
Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

213
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
213
Other Disorders of Digestive System01:30

Other Disorders of Digestive System

778
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
778
Gastritis III: Clinical Manifestations and Management01:23

Gastritis III: Clinical Manifestations and Management

214
The clinical manifestations of gastritis can vary depending on the cause and type of gastritis, but some common symptoms may include the following.
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...
214
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

331
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Renal Manifestations in VEXAS Syndrome: A Systematic Review of Clinical Features, Pathology, and Outcomes.

Mediterranean journal of rheumatology·2026
Same author

Exploring Cryoglobulinemia's Clinical Odyssey: A Case Series.

EJHaem·2025
Same author

Acute tubular injury and Acute Interstitial Nephritis Secondary to Cocaine Use.

Journal of Brown hospital medicine·2025
Same author

Renal manifestations in adult-onset Still's disease: a systematic review.

Rheumatology international·2024
Same author

A pragmatic calibration of the ROX index to predict outcome of nasal high-flow therapy in India.

Journal of critical care·2024
Same author

Diagnostic Dilemma in a Case of Necrotizing Lymphadenitis With Macrophage Activation Syndrome.

Cureus·2023

Related Experiment Video

Updated: Jun 23, 2025

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

15.9K

Multiorgan Dysfunction in a Patient With Adult-Onset Still's Disease Flare: A Case Report.

Akhila Arya P V1, Deepak R Vangipuram2, Madhumita Rondla3

  • 1Internal Medicine, Bridgeport Hospital, Stratford, USA.

Cureus
|June 17, 2024
PubMed
Summary

Adult-onset Still's disease (AOSD) can cause heart failure, leading to kidney and liver dysfunction. Prompt treatment of AOSD and heart failure improved organ function, but cardiac function recovery was incomplete.

Keywords:
acute tubular injuryadult-onset still’s disease (aosd)fulminant myocarditisischemic hepatitismultiorgan dysfunction

More Related Videos

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

7.2K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

19.9K

Related Experiment Videos

Last Updated: Jun 23, 2025

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
07:50

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts

Published on: September 20, 2018

15.9K
An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis
06:35

An Immunohistopathologic Study to Profile the Folate Receptor Beta Macrophage and Vascular Immune Microenvironment in Giant Cell Arteritis

Published on: February 8, 2019

7.2K
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
04:44

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

19.9K

Area of Science:

  • Rheumatology
  • Cardiology
  • Hepatology
  • Nephrology

Background:

  • Adult-onset Still's disease (AOSD) is a rare systemic inflammatory disorder.
  • Multisystemic involvement in AOSD can affect cardiac, hepatic, and renal functions.
  • Understanding these complications is crucial for patient management.

Observation:

  • A 71-year-old female patient with AOSD presented with heart failure.
  • Impaired renal and hepatic function were noted, attributed to low cardiac output and congestive hepatopathy.
  • Myocardial dysfunction was suspected to be due to AOSD-related myocarditis or systemic inflammation.

Findings:

  • Treatment with glucocorticoids and anakinra for AOSD, plus heart failure management, led to full hepatic and renal function recovery.
  • Cardiac function remained compromised, with persistent low ejection fraction and global hypokinesia.
  • This case highlights the complex interplay of AOSD and cardiovascular compromise.

Implications:

  • A systematic approach is vital for managing multiorgan dysfunction in AOSD.
  • Early recognition and treatment of cardiac involvement in AOSD are essential.
  • Further research into cardiac manifestations of AOSD is warranted.