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A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion
Published on: November 12, 2020
A Case Series of Retinal Artery Occlusion: When Time Is of the Essence
Mohd Faizal Zokri1, Othmaliza Othman1
1Ophthalmology, University Kebangsaan Malaysia Medical Centre, Kuala Lumpur, MYS.
Insights
Promptly treating retinal artery occlusions (RAO) is crucial for visual recovery. Early presentation significantly improves outcomes, while delayed treatment often leads to irreversible vision loss.
Area of Science:
- Ophthalmology
- Vascular Medicine
Background:
- Retinal artery occlusions (RAO) are medical emergencies with significant visual consequences.
- Understanding diverse etiologies and optimizing management are critical for patient outcomes.
Observation:
- Three cases of RAO are presented: central RAO secondary to chronic myeloid leukemia, branch RAO post-percutaneous transluminal coronary angioplasty, and central RAO due to vasospastic syndrome.
- Visual recovery varied significantly based on presentation time; early intervention (within 4 hours) yielded good results, whereas late presentation (7-8 hours) resulted in poor outcomes.
Findings:
- Etiologies included hypercoagulable states, thromboembolic events, and vasospasm.
- Timely presentation is the most significant factor influencing visual prognosis in RAO.
- Multidisciplinary approaches may be necessary for effective RAO detection and management.
Implications:
- Prompt diagnosis and management of RAO are essential to prevent irreversible vision loss.
- Further research into novel treatment strategies for RAO is warranted.
- Patient education regarding the urgency of RAO symptoms is vital.
Abstract:
This case series discusses the presentation, etiologies, and management of retinal artery occlusions in three patients. The first case was diagnosed as right eye central retinal artery occlusion (CRAO) secondary to a hypercoagulable state as the patient had been newly diagnosed with chronic myeloid leukemia. The second case had right branch retinal artery occlusion (RAO) secondary to a thromboembolic event following a percutaneous transluminal coronary angioplasty procedure. The third case involved a right eye CRAO secondary to vasospastic syndrome. The first case had good visual recovery as the patient presented to us within four hours of the onset. In contrast, the second and third cases presented after seven to eight hours, resulting in poor visual recovery. Though several measures have been devised to reverse the occlusion, the final visual prognosis still depends on the degree of occlusion and the time of presentation, as late presentation is usually associated with irreversible visual loss. Detection of RAO may require a multidisciplinary team approach, and proper and timely management may reverse the ischemic state of the retina.
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