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Updated: Jun 23, 2025

Tail Vein Transection Bleeding Model in Fully Anesthetized Hemophilia A Mice
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The Evolution of Hemophilia Therapeutics: An Illustrated Review

María G Español1,2, Jessica N Mistretta1, Michael D Tarantino1,3

  • 1The Bleeding & Clotting Disorders Institute, Peoria, IL.

Research and Practice in Thrombosis and Haemostasis
|June 17, 2024
PubMed

Hemophilia is a rare genetic bleeding disorder historically associated with high morbidity and mortality. Some individuals with hemophilia suffer associated chronic joint disease, chronic pain, and other physical and mental health challenges. In the last 50 years, a better understanding of the pathophysiology of the disease has resulted in extraordinary therapeutic advances leading to enhanced quality of life and increased life expectancy. We present an illustrated review of the evolution of hemophilia treatment from the development of non-factor therapies to gene therapy.

Keywords:
Hemophiliableeding disordergene therapyhemophilia treatmentillustrated reviewtreatment

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