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Immunotherapy: The Fourth Domain in Oral Cancer Therapeutics

Ruby Dwivedi1, Ayushi Jain1, Shalini Gupta1

  • 1Department of Oral Pathology and Microbiology, Faculty of Dental Sciences, King George's Medical University, Shahmina Road, Chowk, Lucknow, Uttar Pradesh 226003 India.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
|June 17, 2024
PubMed

Insights

Immunotherapy shows promise as a fourth-line treatment for oral cancer. Identifying biomarkers and patient selection criteria is crucial for personalized immunotherapy response prediction in head and neck cancer.

Area of Science:

  • Oncology
  • Immunology
  • Head and Neck Cancer Research

Background:

  • Oral cancer, a subset of head and neck cancers, has high global prevalence, incidence, and mortality.
  • Immune-modulatory therapies, harnessing the patient's immune system, present a promising avenue for oral cancer treatment.

Purpose of the Study:

  • To evaluate the potential of immunotherapy as a fourth-line therapeutic modality for oral cancer.
  • To review existing literature on immunotherapy applications in oral cancer treatment.

Main Methods:

  • A comprehensive literature search was conducted in MEDLINE and Google Scholar.
  • Included studies comprised clinical trials, meta-analyses, and preclinical research (human, animal, cell line) published in peer-reviewed journals.
  • A total of 97 relevant articles were included in the review.

Main Results:

  • Various immunotherapies have been explored in oral cancer studies and clinical trials.
  • Identifying precise biomarkers for genome-based targeted agents is essential.
  • Parameters for selecting patients likely to benefit from immunotherapy require further definition.

Conclusions:

  • Immunotherapy holds significant potential as a future treatment for oral cancer.
  • Further research is needed to establish predictive values for tumor mutational burden and mutational signatures for personalized treatment response.
  • Optimizing patient selection is key to maximizing immunotherapy efficacy in head and neck cancer.
Keywords:
Head and neck cancerImmunotherapyOral cancerPDL-1Pembrolizumab

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