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Related Experiment Video

Updated: Jun 23, 2025

Author Spotlight: Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke
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Multiparametric Brain Hemodynamics Imaging Using a Combined Ultrafast Ultrasound and Photoacoustic System.

Haoyang Chen1,2, Shubham Mirg1,2, Prameth Gaddale1

  • 1Department of Biomedical Engineering, The Pennsylvania State University, University Park, PA, 16802, USA.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|June 17, 2024
PubMed
Summary

A new multimodal functional ultrasound and photoacoustic (fUSPA) imaging platform enables high-resolution mapping of brain hemodynamics, revealing distinct cerebrovascular reactivity in arteries and veins.

Keywords:
Brain hemodynamicsCerebrovascular reactivityFunctional ultrasoundMultimodal imagingPhotoacoustic imaging

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Medical Imaging

Background:

  • Understanding brain hemodynamics is crucial for neuro-disease research.
  • Current imaging technologies have limitations in resolution and sensitivity.
  • Neurovascular coupling involves complex, interdependent hemodynamic parameters.

Purpose of the Study:

  • To develop a multimodal functional ultrasound and photoacoustic (fUSPA) imaging platform.
  • To quantitatively map cerebral blood volume (CBV), cerebral blood flow (CBF), and oxygen saturation (SO2) dynamics.
  • To investigate brain-wide cerebrovascular reactivity (CVR) at single-vessel resolution.

Main Methods:

  • Integration of ultrafast ultrasound and multispectral photoacoustic imaging.
  • Development of a compact, head-mountable fUSPA device.
  • Application of the system to study CVR in response to hypercapnia stimulation.

Main Results:

  • The fUSPA system enables high spatiotemporal resolution mapping of CBV, CBF, and SO2.
  • Cortical arteries and veins show differential CVR during hypercapnia.
  • Resting-state CBV oscillations exhibit consistent anti-correlation between arteries and veins.

Conclusions:

  • The fUSPA platform offers unique capabilities for multiparametric brain imaging.
  • This technology can advance the investigation of complex brain function mechanisms.
  • Findings highlight distinct vascular responses relevant to neurovascular coupling.