Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Anticancer drug pharmacodynamics.

G Powis

    Cancer Chemotherapy and Pharmacology
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Understanding anticancer drug pharmacodynamics, the link between drug concentration and patient response, is crucial for effective cancer therapy. Current knowledge gaps in pharmacodynamics hinder optimal drug dosage and treatment outcomes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    PATHOME: an algorithm for accurately detecting differentially expressed subpathways.

    Oncogene·2014
    Same author

    PI-3-Kinase inhibitors in colorectal cancer.

    Current cancer drug targets·2010
    Same author

    In vitro metabolism of [(3)H]2,6-dinitrotoluene by human and rat liver.

    Toxicology in vitro : an international journal published in association with BIBRA·2010
    Same author

    Adenine and pyridine nucleotide concentrations and relationships to 2,6-dinitrotoluene metabolism in cultured rat liver slices.

    Toxicology in vitro : an international journal published in association with BIBRA·2010
    Same author

    Increased thioredoxin-1 inhibits SSAT expression in MCF-7 human breast cancer cells.

    Biochemical and biophysical research communications·2003
    Same author

    DNA microarray reveals increased expression of thioredoxin peroxidase in thioredoxin-1 transfected cells and its functional consequences.

    Advances in experimental medicine and biology·2002

    Area of Science:

    • Pharmacology
    • Oncology
    • Drug Metabolism

    Background:

    • Extensive data exists on anticancer drug pharmacokinetics (how the body affects the drug).
    • Limited information is available regarding their pharmacodynamics (how the drug affects the body).
    • Pharmacodynamics describes the relationship between drug concentration and therapeutic or toxic effects.

    Purpose of the Study:

    • To highlight the importance of pharmacodynamic data in cancer therapy.
    • To identify the limitations imposed by the lack of pharmacodynamic knowledge.
    • To suggest methods for improving the understanding of anticancer drug pharmacodynamics.

    Main Methods:

    • Literature review of existing pharmacokinetic and pharmacodynamic studies on anticancer drugs.
    • Analysis of the relationship between drug concentration, therapeutic response, and toxic effects.

    Related Experiment Videos

  • Identification of knowledge gaps in the field.

    • Main Results:

    • A significant disparity exists between available pharmacokinetic and pharmacodynamic data for anticancer agents.
    • Few studies report on the relationship between toxic responses and pharmacokinetic parameters in humans.
    • Even fewer studies correlate therapeutic responses with pharmacokinetic parameters.

    Conclusions:

    • The scarcity of pharmacodynamic information is a major impediment to optimizing anticancer drug therapy.
    • Integrating pharmacokinetic and pharmacodynamic data is essential for designing effective drug dosage regimens.
    • Further research is needed to elucidate the pharmacodynamics of anticancer drugs to improve patient outcomes.