Opportunities for Improving Detection of Cancer Predisposition Syndromes in Pediatric Solid Tumor Patients
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View abstract on PubMed
Summary
This summary is machine-generated.Pediatric oncology providers collect insufficient family history, potentially missing cancer predisposition syndromes (CPS). Interventions are needed to improve family history documentation for better genetic counseling referrals.
Area Of Science
- Pediatric Oncology
- Genetics
- Cancer Predisposition Syndromes
Background
- Detecting cancer predisposition syndromes (CPS) relies on identifying risk factors like tumor type and family history.
- Pediatric oncology providers (POPs) are crucial for this detection, but their family history collection adequacy is unknown.
Purpose Of The Study
- To evaluate the adequacy of family history information collected by pediatric oncology providers (POPs).
- To compare POPs' family history collection with genetic counselors' performance.
- To assess if documented family history meets criteria for genetic counseling referral guidelines.
Main Methods
- Retrospective chart review of pediatric solid tumor patients (<18 years) referred for CPS evaluation.
- Assessed POP adherence to American Society of Clinical Oncology (ASCO) family history recommendations.
- Evaluated family history sufficiency against ACMG, UJ, and MIPOGG guidelines.
Main Results
- POPs met ASCO family history metrics in only 3% of cases, compared to 99% for genetic counselors.
- POPs failed to document sufficient family history for referral criteria in most cases (74-79%).
Conclusions
- POPs demonstrate poor performance in collecting family history, potentially leading to missed CPS referrals.
- Interventions are necessary to improve family history collection by POPs for enhanced CPS detection.
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