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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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The nucleolus is the most prominent substructure of the nucleus. When it was first discovered, it was considered to be an isolated organelle that forms fibrils and granules. In 1931, the relationship between the nucleolus and chromosomes was first described by Heitz. He observed that the appearance and size of nucleolus varies depending on the stage of the cell cycle. He also noticed constricted regions on different chromosomes clustered together at definite cell cycle stages. These regions,...
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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Updated: Jun 23, 2025

Stimulation of Notch Signaling in Mouse Osteoclast Precursors
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Retraction Note: LncRNA UCA1 affects osteoblast proliferation and differentiation by regulating BMP-2 expression.

R-F Zhang1, J-W Liu, S-P Yu

  • 1National & Regional United Engineering Laboratory of Tissue Engineering, Department of Orthopaedics, Southwest Hospital, Army Medical University (Third Military Medical University), Chongqing, China.

European Review for Medical and Pharmacological Sciences
|June 17, 2024
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Summary

This study on long noncoding RNA UCA1 and osteoblast function is retracted due to data validation issues. The findings on UCA1 regulating BMP-2 expression require further confirmation.

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Area of Science:

  • Molecular Biology
  • Cell Biology
  • Biochemistry

Context:

  • Osteoblast proliferation and differentiation are crucial for bone health.
  • Long noncoding RNAs (lncRNAs) are emerging as key regulators in various biological processes.
  • The role of lncRNA UCA1 in bone metabolism was under investigation.

Purpose:

  • To investigate the role of lncRNA UCA1 in regulating osteoblast proliferation and differentiation.
  • To explore the mechanism by which UCA1 influences bone formation, specifically its regulation of Bone Morphogenetic Protein-2 (BMP-2) expression.

Summary:

  • The study aimed to demonstrate that lncRNA UCA1 promotes osteoblast proliferation and differentiation.
  • It proposed that UCA1 exerts its effects by upregulating the expression of BMP-2.
  • The findings suggested a potential therapeutic target for bone-related diseases.

Impact:

  • The potential impact on understanding bone development and diseases like osteoporosis was highlighted.
  • The study aimed to provide insights into novel therapeutic strategies targeting lncRNA UCA1 for bone regeneration.
  • However, the retraction indicates that these findings require further validation and may not be reproducible.