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Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
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Mendelian randomization study on association between grip strength and BMD in different age groups.

Yingying Zhu1, Kede Chi2, Jiaci Wang1

  • 1Department of Geriatric Medicine, Zhongshan Hospital of Traditional Chinese Medicine, Zhong Shan, 528400, Guangdong Province, China.

Journal of Bone and Mineral Metabolism
|June 17, 2024
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Summary

Reduced grip strength is linked to increased osteoporosis risk and declining lumbar spine bone mineral density (BMD) in adults aged 45-60. This Mendelian randomization study confirms a causal relationship.

Keywords:
Different agesGrip strengthMendelian randomizationOsteoporosis risk

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Area of Science:

  • Genetics
  • Osteoporosis Research
  • Aging Studies

Background:

  • Bone mineral density (BMD) is crucial for skeletal health.
  • Grip strength may indicate overall physical health and bone status.
  • Understanding the causal link between grip strength and BMD is important for aging populations.

Purpose of the Study:

  • To investigate the causal relationship between grip strength and BMD using Mendelian randomization.
  • To examine age- and body-part-specific associations.

Main Methods:

  • Utilized pooled genome-wide association studies (GWAS) data.
  • Employed Mendelian randomization with inverse variance weighted (IVW) as the primary method.
  • Assessed hand grip strength as exposure and total body BMD as outcome, with sensitivity analyses.

Main Results:

  • A causal link was found between decreased grip strength and osteoporosis risk in the 45-60 age group.
  • Reduced grip strength was associated with a higher risk of declining lumbar spine BMD.
  • No significant associations were observed in other age groups.

Conclusions:

  • Decreased grip strength is causally associated with increased osteoporosis risk in individuals aged 45-60.
  • Lumbar spine BMD decline is linked to reduced grip strength in this age group.