Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Determination01:51

Determination

18.4K
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
18.4K
Neurulation01:30

Neurulation

41.8K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
41.8K
Gastrulation01:56

Gastrulation

57.2K
Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata...
57.2K
Notch Signaling Pathway03:14

Notch Signaling Pathway

4.2K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.2K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

760
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
760
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

3.6K
A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Functional architecture of cardiac TF regulatory landscapes in control of mammalian heart development.

bioRxiv : the preprint server for biology·2026
Same author

Hand1 gene replacement with Hand2 reveals overlap in function with unique occurrence of omphalocele and heart defects.

Development (Cambridge, England)·2025
Same author

Maturation of human cardiac organoids enables complex disease modeling and drug discovery.

Nature cardiovascular research·2025
Same author

PDGFRA is a conserved HAND2 effector during early cardiac development.

Nature cardiovascular research·2024
Same author

Corrigendum to "Structure-function studies of the bHLH phosphorylation domain of TWIST1 in prostate cancer cells" [Neoplasia 17 (2014) 85].

Neoplasia (New York, N.Y.)·2024
Same author

Identification and characterization of Hand2 upstream genomic enhancers active in developing stomach and limbs.

Developmental dynamics : an official publication of the American Association of Anatomists·2023
Same journal

Peptidomics in the Spotlight: Advanced Sample Treatment Techniques and Analytical Insights.

Advances in experimental medicine and biology·2026
Same journal

Methods for the Investigation of Protein-Ligands Interactions.

Advances in experimental medicine and biology·2026
Same journal

Sample Preparation Strategies for Microbial Cell Surface Proteomics: Integrating Shaving and Shotgun Approaches.

Advances in experimental medicine and biology·2026
Same journal

Proteomic Sample Preparation for the Petroleum Industry: A Biocorrosion Case Study.

Advances in experimental medicine and biology·2026
Same journal

Proteomic and Functional Comparison of Extracellular Vesicles from Wild-Type and Lyn-Deficient Stromal Cells.

Advances in experimental medicine and biology·2026
Same journal

Proteomic Analysis of Histone Sequence Variants and Post-translationally Modified Forms.

Advances in experimental medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Jun 23, 2025

Analysis of Neural Crest Migration and Differentiation by Cross-species Transplantation
09:03

Analysis of Neural Crest Migration and Differentiation by Cross-species Transplantation

Published on: February 7, 2012

22.8K

Neural Crest.

Bijoy D Thattaliyath1, Anthony B Firulli2

  • 1Department of Pediatrics, Stead Family Children's Hospital, University of Iowa, Iowa, IA, USA.

Advances in Experimental Medicine and Biology
|June 17, 2024
PubMed
Summary
This summary is machine-generated.

Cardiac neural crest cells are crucial for forming the heart

Keywords:
22q11.2 deletion syndromeAP-2AortaCHARGE syndromeCNCCsCardiac neural crest cellsCardiac regenerationConduction systemConnexin 43DiGeorge syndromeE-cadherinEMTEctodermEctomesenchymal cellsEndodermEndothelin-1Epithelial-to-mesenchymal transitionHeart loopingJacobsen syndromeLEOPARD syndromeNervous systemNeural tubeNoonan syndromeOutflow tractParathyroid glandPatent ductus arteriosusPax3Pharyngeal arch arteriesPulmonary trunkSOX10SRYSemaphorinSnailTWIST1ThymusThyroid glandTreacher Collins syndromeVelocardiofacial syndromeZIC1

More Related Videos

Isolation and Culture of Neural Crest Cells from Embryonic Murine Neural Tube
12:48

Isolation and Culture of Neural Crest Cells from Embryonic Murine Neural Tube

Published on: June 2, 2012

17.3K
Culturing and Manipulation of O9-1 Neural Crest Cells
08:32

Culturing and Manipulation of O9-1 Neural Crest Cells

Published on: October 9, 2018

10.1K

Related Experiment Videos

Last Updated: Jun 23, 2025

Analysis of Neural Crest Migration and Differentiation by Cross-species Transplantation
09:03

Analysis of Neural Crest Migration and Differentiation by Cross-species Transplantation

Published on: February 7, 2012

22.8K
Isolation and Culture of Neural Crest Cells from Embryonic Murine Neural Tube
12:48

Isolation and Culture of Neural Crest Cells from Embryonic Murine Neural Tube

Published on: June 2, 2012

17.3K
Culturing and Manipulation of O9-1 Neural Crest Cells
08:32

Culturing and Manipulation of O9-1 Neural Crest Cells

Published on: October 9, 2018

10.1K

Area of Science:

  • Developmental Biology
  • Cardiovascular Science
  • Genetics

Background:

  • Cardiac neural crest cells play a vital role in the development of the cardiac arterial pole.
  • These cells are essential for the formation of the septum separating the systemic and pulmonary arteries.
  • They also support the development of pharyngeal arch derivatives like the great arteries, thymus, thyroid, and parathyroids.

Purpose of the Study:

  • To elucidate the multifaceted roles of cardiac neural crest cells in cardiovascular development.
  • To understand their influence on the formation of great arteries and other pharyngeal arch derivatives.
  • To highlight their potential involvement in congenital cardiac outflow malformations.

Main Methods:

  • Utilizing avian models to study the contribution and function of cardiac neural crest cells.
  • Employing mouse models to identify genes associated with cardiac neural crest cell function.
  • Analyzing the complex tissue interactions within the caudal pharynx and outflow tract.

Main Results:

  • Cardiac neural crest cells are critical for septation of the cardiac arterial pole.
  • These cells directly support the development of great arteries and other pharyngeal derivatives.
  • They indirectly influence the secondary heart field by modulating pharyngeal signaling.

Conclusions:

  • Cardiac neural crest cells are indispensable for normal cardiovascular development.
  • Their strategic location makes them susceptible to perturbations, potentially leading to malformations.
  • A deeper understanding of these cells is essential for addressing congenital cardiac outflow defects.