Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

632
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
632
Overview of Metabolism01:40

Overview of Metabolism

29.8K
Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
29.8K
Overview of Carbohydrate Metabolism01:19

Overview of Carbohydrate Metabolism

902
Carbohydrate metabolism is a fundamental biochemical process that ensures a constant supply of energy to living cells. The most important carbohydrate is glucose, which can be broken down via glycolysis to enter into the Krebs cycle and eventually lead to the production of ATP through oxidative phosphorylation.
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
902
Specialized Characteristics of Cardiac Muscles01:27

Specialized Characteristics of Cardiac Muscles

2.4K
The primary role of cardiac muscles is to propel blood throughout the cardiovascular system. The cardiac muscle cells, or cardiomyocytes, exhibit specialized characteristics that allow them to perform this function.
Cardiac muscle cells are smaller than skeletal muscles, averaging 10–20 mm in diameter and 50–100 mm in length. However, they have large energy demands for continuous contraction and relaxation. This energy is almost exclusively derived from aerobic metabolism of energy...
2.4K
Cardiac Output I:Effect of Heart Rate on Cardiac Output01:19

Cardiac Output I:Effect of Heart Rate on Cardiac Output

735
Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
735
What is Metabolism?00:52

What is Metabolism?

113.9K
Overview
113.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mitochondria directly interact with the nuclear pore complex.

Nature·2026
Same author

Paracrine IGFBP3 spatially coordinates IGF signaling to induce myocardial regeneration in mice.

Journal of molecular and cellular cardiology·2025
Same author

An FDA-approved drug structurally and phenotypically corrects the K210del mutation in genetic cardiomyopathy models.

The Journal of clinical investigation·2025
Same author

Induced Cytokinesis Generates Highly Proliferative Mononuclear Cardiomyocytes at the Expense of Contractility.

Circulation·2025
Same author

Vascular HIF2 Signaling Prevents Cardiomegaly, Alveolar Congestion, and Capillary Remodeling During Chronic Hypoxia.

Arteriosclerosis, thrombosis, and vascular biology·2025
Same author

Hypoxia inducible factor-dependent upregulation of Agrp in glomus type I cells of the carotid body.

Molecular metabolism·2025
Same journal

Peptidomics in the Spotlight: Advanced Sample Treatment Techniques and Analytical Insights.

Advances in experimental medicine and biology·2026
Same journal

Methods for the Investigation of Protein-Ligands Interactions.

Advances in experimental medicine and biology·2026
Same journal

Sample Preparation Strategies for Microbial Cell Surface Proteomics: Integrating Shaving and Shotgun Approaches.

Advances in experimental medicine and biology·2026
Same journal

Proteomic Sample Preparation for the Petroleum Industry: A Biocorrosion Case Study.

Advances in experimental medicine and biology·2026
Same journal

Proteomic and Functional Comparison of Extracellular Vesicles from Wild-Type and Lyn-Deficient Stromal Cells.

Advances in experimental medicine and biology·2026
Same journal

Proteomic Analysis of Histone Sequence Variants and Post-translationally Modified Forms.

Advances in experimental medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Jun 23, 2025

Investigating Cardiac Metabolism in the Isolated Perfused Mouse Heart with Hyperpolarized [1-13C]Pyruvate and 13C/31P NMR Spectroscopy
14:56

Investigating Cardiac Metabolism in the Isolated Perfused Mouse Heart with Hyperpolarized [1-13C]Pyruvate and 13C/31P NMR Spectroscopy

Published on: April 21, 2023

1.4K

Cardiac Metabolism.

Silvia Martin-Puig1,2, Ivan Menendez-Montes3

  • 1Department of Metabolic and Immune Diseases, Institute for Biomedical Research "Sols-Morreale", National Spanish Research Council, CSIC, Madrid, Spain. smartinp@cnic.es.

Advances in Experimental Medicine and Biology
|June 17, 2024
PubMed
Summary
This summary is machine-generated.

Heart cell metabolism shifts from glycolysis to oxidative phosphorylation during development and injury. Understanding diverse cardiac cell bioenergetics is key to improving heart repair and preventing heart failure.

Keywords:
Cardiac developmentCardiac metabolismCardiac regenerationFatty acid oxidationGlycolysisHypoxiaOxidative stressPentose phosphate pathway

More Related Videos

Methods for the Determination of Rates of Glucose and Fatty Acid Oxidation in the Isolated Working Rat Heart
12:24

Methods for the Determination of Rates of Glucose and Fatty Acid Oxidation in the Isolated Working Rat Heart

Published on: September 28, 2016

14.7K
Analyzing Oxygen Consumption Rate in Primary Cultured Mouse Neonatal Cardiomyocytes Using an Extracellular Flux Analyzer
11:26

Analyzing Oxygen Consumption Rate in Primary Cultured Mouse Neonatal Cardiomyocytes Using an Extracellular Flux Analyzer

Published on: February 13, 2019

8.7K

Related Experiment Videos

Last Updated: Jun 23, 2025

Investigating Cardiac Metabolism in the Isolated Perfused Mouse Heart with Hyperpolarized [1-13C]Pyruvate and 13C/31P NMR Spectroscopy
14:56

Investigating Cardiac Metabolism in the Isolated Perfused Mouse Heart with Hyperpolarized [1-13C]Pyruvate and 13C/31P NMR Spectroscopy

Published on: April 21, 2023

1.4K
Methods for the Determination of Rates of Glucose and Fatty Acid Oxidation in the Isolated Working Rat Heart
12:24

Methods for the Determination of Rates of Glucose and Fatty Acid Oxidation in the Isolated Working Rat Heart

Published on: September 28, 2016

14.7K
Analyzing Oxygen Consumption Rate in Primary Cultured Mouse Neonatal Cardiomyocytes Using an Extracellular Flux Analyzer
11:26

Analyzing Oxygen Consumption Rate in Primary Cultured Mouse Neonatal Cardiomyocytes Using an Extracellular Flux Analyzer

Published on: February 13, 2019

8.7K

Area of Science:

  • Cardiovascular Biology
  • Cellular Metabolism
  • Regenerative Medicine

Background:

  • Cardiac cells exhibit context-dependent metabolic signatures crucial for function, survival, and adaptation.
  • Adult cardiomyocytes rely on oxidative metabolism, which generates reactive oxygen species contributing to cardiovascular disease.
  • Cardiac metabolism undergoes significant dynamic changes from embryonic development to adulthood.

Purpose of the Study:

  • To explore the dynamic metabolic landscape of the heart across different developmental stages and in response to injury.
  • To highlight the importance of understanding bioenergetics in various cardiac cell populations beyond cardiomyocytes.
  • To identify metabolic rewiring as a potential therapeutic strategy for heart regeneration and failure prevention.

Main Methods:

  • Review of existing literature on cardiac metabolism during development and disease.
  • Analysis of metabolic shifts in cardiomyocytes from fetal to adult stages.
  • Examination of metabolic adaptations in response to cardiac injury.

Main Results:

  • Early cardiogenesis relies on anaerobic glycolysis, transitioning to oxidative phosphorylation in mature cardiomyocytes.
  • Cardiac injury triggers metabolic rewiring, reactivating embryonic programs or utilizing alternative substrates.
  • Metabolic profiles of non-cardiomyocyte cardiac cells (endothelial, fibroblasts, immune cells) remain largely understudied.

Conclusions:

  • Cardiac metabolism is highly adaptable, playing a central role in organ homeostasis and response to damage.
  • Limited knowledge of non-cardiomyocyte bioenergetics hinders comprehensive understanding of cardiac function.
  • Targeting metabolic pathways in diverse cardiac cells offers promising avenues for therapeutic interventions in heart disease.