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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Association between chronic kidney disease stages and changes in ambulatory blood pressure monitoring parameters

André Murad Nagahama1, Vanessa Dos Santos Silva1, Vanessa Burgugi Banin1

  • 1Universidade Estadual Paulista "Júlio de Mesquita Filho", Faculdade de Medicina, Botucatu, SP, Brazil.

Jornal Brasileiro De Nefrologia
|June 17, 2024
PubMed

Insights

Advanced chronic kidney disease (CKD) stages correlate with significant changes in ambulatory blood pressure monitoring (ABPM) patterns, including reduced nocturnal dipping and increased blood pressure variability.

Area of Science:

  • Nephrology
  • Cardiology
  • Hypertension Management

Background:

  • Blood pressure (BP) management is crucial for arterial hypertension (AH) in chronic kidney disease (CKD).
  • CKD patients exhibit distinct BP patterns during ambulatory blood pressure monitoring (ABPM).

Purpose of the Study:

  • To investigate the relationship between progressive CKD stages and alterations in ABPM parameters.
  • To understand how CKD progression impacts BP variability and dipping patterns.

Main Methods:

  • Cross-sectional study of 851 patients undergoing ABPM.
  • Analysis of ABPM parameters in relation to CKD stages (3a-5).
  • Confounding factors included age, sex, BMI, smoking, CKD cause, and antihypertensive use.

Main Results:

  • Systolic BP (SBP) associated with CKD stages 3b and 5.
  • Increased SBP variability linked to CKD stages 3a, 4, and 5.
  • Reduced SBP and diastolic BP (DBP) dipping observed in advanced CKD stages (4 and 5).

Conclusions:

  • Advanced CKD stages are significantly associated with diminished nocturnal BP dipping.
  • Greater BP variability is a characteristic of later stages of chronic kidney disease.
Abstract

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