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Updated: May 31, 2026

Applying Microfluidics to Electrophysiology

Applying Microfluidics to Electrophysiology

Published on: October 1, 2007

Microfluidic Interfaces for Chronic Bidirectional Access to the Brain.

Simone Marcigaglia^1,2, Robin De Plus^1,2, Charysse Vandendriessche^3,4

¹Neuroelectronics Research Flanders (NERF), Leuven, 3000, Belgium.

Advanced Healthcare Materials

|June 17, 2024

Summary

This summary is machine-generated.

Two-photon polymerization creates microcatheters for precise brain drug delivery and cerebrospinal fluid sampling in research models. This technology offers a less disruptive method for chronic neurological studies and potential biomarker tracking.

Keywords:

brain disease cerebrospinal fluid convection‐enhanced delivery liquid biopsy

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Last Updated: May 31, 2026

Applying Microfluidics to Electrophysiology

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Published on: October 1, 2007

Brain Slice Stimulation Using a Microfluidic Network and Standard Perfusion Chamber

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Area of Science:

Biomedical Engineering
Neuroscience
Additive Manufacturing

Background:

Two-photon polymerization (TPP) is a high-resolution additive manufacturing technique.
Biocompatible and non-cytotoxic resins are crucial for biomedical applications.
Chronic fluidic access to the brain is needed for preclinical research.

Purpose of the Study:

To develop microfluidic interfaces using TPP for brain drug delivery and cerebrospinal fluid (CSF) sampling.
To evaluate the performance of these microcatheters in preclinical models.
To assess the potential for simultaneous drug delivery and biomarker tracking.

Main Methods:

Utilized two-photon polymerization to fabricate microcatheter interfaces.
Tested microcatheter infusion in a brain phantom and in mice.
Assessed longitudinal CSF sampling over 250 days in vivo.
Evaluated blood-CSF barrier integrity and sample suitability for molecular analysis.

Main Results:

Microcatheters enabled more localized drug distribution and reduced backflow compared to controls.
In vivo injections were faster, more precise, and less disruptive.
Longitudinal CSF sampling was successful for up to 250 days.
Blood-CSF barrier remained intact, and CSF samples were suitable for biomarker analysis.

Conclusions:

TPP is a versatile technique for creating microfluidic interfaces for the brain.
These interfaces facilitate precise drug delivery and chronic CSF sampling in preclinical models.
The technology holds significant translational potential for neurological disease research and treatment.