Nucleic acid sequence database VI: Retroviral oncogenes and cellular proto-oncogenes

The databases of the Protein Identification Resource at the National Biomedical Research Foundation (NBRF) contain nucleic acid and protein sequences from 18 retroviral oncogenes (v-onc) and 8 cellular proto-oncogenes (c-onc). Comparison of the sequences between the v-onc and c-onc genes reveals: (i) The c-src, c-abl, c-mos, c-fos, c-ras, c-myb, c-myc, and c-sis genes contain coding regions that are highly conserved in the respective v-onc genes with a small number of base changes. (ii) There are more transitions than transversions. (iii) Some of these base changes are silent mutations and others generate amino acid substitutions in the viral proteins. The causes of these base changes in the coding sequences and the significance to oncogenic transformation of the amino acid substitutions in the viral proteins remain to be determined.