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Butorphanol.

I J Pachter, R P Evens

    Drug and Alcohol Dependence
    |February 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Butorphanol offers effective pain relief for moderate to severe pain in 90% of patients. This synthetic analgesic has a favorable side effect profile, making it a potent option for surgical and pain management needs.

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    Area of Science:

    • Pharmacology
    • Anesthesiology

    Background:

    • Butorphanol is a synthetic agonist-antagonist analgesic.
    • It belongs to the 14-hydroxymorphinan series.

    Purpose of the Study:

    • To summarize the pharmacological effects and clinical applications of butorphanol.
    • To evaluate its efficacy and side effect profile in pain management and surgical anesthesia.

    Main Methods:

    • Review of animal studies on butorphanol's effects.
    • Analysis of clinical data regarding its use in moderate to severe pain.
    • Assessment of its role in surgical anesthetic procedures.

    Main Results:

    • Demonstrates analgesia, antitussive effects, and opiate antagonism in animal models.

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  • Provides good to excellent pain relief in 90% of patients with parenteral administration.
  • Indicated for preoperative, intraoperative, and postoperative pain management.

    • Conclusions:

    • Butorphanol is a potent analgesic with a favorable side effect profile.
    • It is effective in managing moderate to severe pain and serves as a valuable agent in surgical anesthesia.
    • Limited respiratory depression and potential for CNS excitation are noted side effects.