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Updated: Jun 23, 2025

Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics
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Author Spotlight: Tracing the Ferroptotic Signatures and Cell Death Dynamics in Medulloblastoma for Advanced Therapeutics

Published on: March 15, 2024

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Disulfidptosis: A new type of cell death

Fei Xiao1, Hui-Li Li1,2, Bei Yang1

  • 1Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.

Apoptosis : an International Journal on Programmed Cell Death
|June 17, 2024
PubMed

Insights

Disulfidptosis is a new cell death pathway. It involves NADPH depletion and cystine accumulation, causing disulfide bonds in actin and cell death, distinct from other programmed cell death types.

Area of Science:

  • Cell Biology
  • Biochemistry
  • Pathology

Background:

  • Discovered a novel cell death pathway termed disulfidptosis.
  • Distinguishable from apoptosis, pyroptosis, autophagy, ferroptosis, and oxeiptosis.
  • Characterized by rapid nicotinamide adenine dinucleotide phosphate (NADPH) depletion and solute carrier family 7 member 11 (SLC7A11) upregulation during glucose starvation.

Purpose of the Study:

  • To review the mechanisms, influencing factors, and disease associations of disulfidptosis.
  • To compare disulfidptosis with established programmed cell death pathways.
  • To explore the application prospects and future research directions for disulfidptosis.

Main Methods:

  • Literature review of disulfidptosis.
  • Analysis of molecular mechanisms.
  • Comparison with other cell death modalities.

Main Results:

  • Disulfidptosis is triggered by glucose starvation, leading to NADPH depletion and SLC7A11 overexpression.
  • Abnormal cystine accumulation results in aberrant disulfide bond formation in actin.
  • Actin cytoskeleton collapse is the terminal event in disulfidptosis.

Conclusions:

  • Disulfidptosis represents a distinct programmed cell death pathway.
  • Understanding disulfidptosis mechanisms offers potential therapeutic targets for related diseases.
  • Further research is needed to fully elucidate its role and applications.
Keywords:
CystineDisulfide bondDisulfidptosisGlucose starvationNADPHSLC7A11

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