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Home-Based Monitor for Gait and Activity Analysis
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Measuring gait parameters from a single chest-worn accelerometer in healthy individuals: a validation study.

N Camerlingo1, X Cai2, L Adamowicz2

  • 1Pfizer, Inc., Cambridge, MA, USA. nunzio.camerlingo@pfizer.com.

Scientific Reports
|June 17, 2024
PubMed
Summary

Chest accelerometers accurately measure gait parameters, matching lumbar sensors. This finding supports using a single chest device for vital signs and gait analysis in digital health trials, reducing participant burden.

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Area of Science:

  • Biomedical Engineering
  • Digital Health Technologies
  • Clinical Trial Methodology

Background:

  • Digital health technologies (DHTs) offer objective health monitoring in real-world settings.
  • Lumbar accelerometers provide reliable gait data, but multiple devices increase participant burden.
  • Chest-worn devices, used for vital signs, could potentially capture gait information.

Purpose of the Study:

  • To validate gait parameters measured by accelerometers integrated into chest-worn devices.
  • To compare gait data from chest and lumbar accelerometers against reference measurements.
  • To assess the feasibility of using a single chest device for multimodal data collection in clinical trials.

Main Methods:

  • Twenty healthy adults participated in in-lab and outside-lab walking tasks.
  • Gait parameters were collected using chest and lumbar accelerometers, with reference data from an instrumented mat and a 6-accelerometer set.
  • Data analysis involved Bland-Altman plots, Pearson's correlation, intraclass correlation, and mixed effects regression models using the SKDH-gait algorithm.

Main Results:

  • Gait parameters derived from chest and lumbar accelerometers demonstrated no significant differences and excellent agreement.
  • Both device placements showed good-to-excellent agreement and strong correlation with reference values.
  • Mixed effects models confirmed no significant effect of device or task on gait parameter validity.

Conclusions:

  • Chest-worn accelerometers are valid for measuring gait parameters, comparable to lumbar placement.
  • A single chest device can simultaneously capture vital signs and gait data, simplifying clinical trial protocols.
  • This approach enhances participant experience and data richness in digital health clinical trials.