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3D-printed ultra-small Brownian viscometers.

Gaszton Vizsnyiczai1,2, Jana Kubacková3, Gergely T Iványi1,4

  • 1HUN-REN Biological Research Centre, Szeged, Institute of Biophysics, Temesvári krt. 62, Szeged, 6726, Hungary.

Scientific Reports
|June 17, 2024
PubMed
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This study introduces a novel microcantilever viscometer for precise viscosity measurements of Newtonian liquids at the microliter scale. The device utilizes Brownian motion of polymer cantilevers for accurate, simple, and integrated viscosity analysis.

Area of Science:

  • Microfluidics and Nanotechnology
  • Materials Science
  • Physical Chemistry

Background:

  • Accurate viscosity measurement in sub-microliter volumes presents significant challenges.
  • Existing methods often require larger sample volumes or complex instrumentation.
  • Development of micro-scale viscometers is crucial for applications in lab-on-a-chip devices and high-throughput screening.

Purpose of the Study:

  • To develop and validate a novel microcantilever-based viscometer for measuring the viscosity of Newtonian liquids.
  • To demonstrate the feasibility of using Brownian motion of microcantilevers for viscosity determination.
  • To provide a simple, accurate, and integrated solution for ultra-low volume viscosity measurements.

Main Methods:

  • Fabrication of micron-sized flexible polymer microcantilevers using two-photon polymerization.
Keywords:
Brownian fluctuationsPower spectral densityTwo-photon polymerizationViscoelastic polymer nanowireViscometer

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  • Tracking the Brownian motion of the cantilever's end using high-accuracy microscopic imaging.
  • Determining hydrodynamic resistance by fitting the power spectral density of cantilever fluctuations.
  • Calibration using water-glycerol mixtures with known viscosities.

    • Main Results:

    • Microcantilevers exhibited pronounced Brownian motion when submerged in liquids.
    • Hydrodynamic resistance showed excellent linear correlation with viscosity.
    • A simple linear calibration method was established.
    • The microviscometer demonstrated accurate viscosity measurements for Newtonian liquids.

    Conclusions:

    • The developed microcantilever viscometer offers a practical and user-friendly method for ultra-low volume viscosity measurements.
    • The device is highly sensitive and requires minimal external instrumentation.
    • Its small size and integration potential make it ideal for lab-on-a-chip applications and microfluidic systems.