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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
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Introduction to Fibroblasts01:09

Introduction to Fibroblasts

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Rudolph Virchow discovered spindle-shaped cells called fibroblasts in 1858. Inactive fibroblasts, called fibrocytes, become activated by various stimuli, such as growth factors and inflammatory cytokines. Activated fibroblasts play a crucial role in wound healing, inflammation, formation of new blood vessels, and cancer progression. Uncontrolled activation of fibroblasts results in fibrosis, the excess deposition of fibrous tissue, which can lead to scarring and affect normal organs. This...
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iPS Cell Differentiation01:22

iPS Cell Differentiation

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Stem Cell Culture01:17

Stem Cell Culture

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

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Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
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  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Stem Cell-based Therapy For Fibrotic Diseases: Mechanisms And Pathways.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Stem Cell-based Therapy For Fibrotic Diseases: Mechanisms And Pathways.

Related Experiment Video

Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes
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Suppression of Pro-fibrotic Signaling Potentiates Factor-mediated Reprogramming of Mouse Embryonic Fibroblasts into Induced Cardiomyocytes

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Stem cell-based therapy for fibrotic diseases: mechanisms and pathways.

Marjan Taherian1,2, Paria Bayati1,2, Nazanin Mojtabavi3,4

  • 1Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Stem Cell Research & Therapy
|June 17, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Fibrosis causes organ scarring and failure. Stem cell therapies show promise for treating fibrosis by modulating immune responses and promoting regeneration, though mechanisms require further study.

Keywords:
Coronavirus infectionsFibrosisInduced pluripotent stem cellsMesenchymal stem cells

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Area of Science:

  • Biomedical Science
  • Regenerative Medicine
  • Immunology

Background:

  • Fibrosis is a pathological scarring process leading to organ failure, affecting major organs like lungs, liver, and heart, and is linked to high morbidity and mortality.
  • Existing fibrotic disorders range from cosmetic scars to severe conditions like systemic sclerosis and idiopathic pulmonary fibrosis, often exacerbated by inflammatory responses and tissue damage.
  • Current therapeutic options to halt or reverse fibrosis are limited, highlighting the urgent need for novel treatment strategies.

Purpose of the Study:

  • To review various stem cell types investigated for anti-fibrotic effects.
  • To discuss the challenges and limitations of clinical applications of stem cells in treating fibrosis.
  • To summarize the mechanisms underlying tissue fibrosis and the pathways employed by stem cells to exert anti-fibrotic effects.
Stem cell therapy

Main Methods:

  • Literature review of studies on stem cell applications for fibrosis.
  • Analysis of general and organ-specific mechanisms of fibrotic processes.
  • Examination of proposed mechanisms by which stem cells attenuate fibrosis.

Main Results:

  • Stem cells possess immunomodulatory and regenerative potential, showing promise as anti-fibrotic agents.
  • Despite potent capabilities, the precise mechanisms and pathways through which stem cells impact fibrosis are not fully understood.
  • Various stem cell types have been investigated, each with unique properties, challenges, and limitations for clinical use.

Conclusions:

  • Stem cell therapy represents a potential therapeutic avenue for fibrotic diseases.
  • Further research is crucial to elucidate the underlying mechanisms of stem cell-mediated anti-fibrotic effects.
  • Understanding these mechanisms will facilitate the development of effective stem cell-based strategies to combat organ fibrosis.