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Updated: Jun 23, 2025

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
Published on: August 20, 2019
[Is this iatrogenic pathology or rare disease?]
O D Yagmurov1, E P Fedotova2, V A Fetisov1,3
1Bureau of Forensic Medical Expertise, St. Petersburg, Russia.
Buerger's disease, a rare inflammatory vascular condition, can present subtly. This case highlights diagnostic challenges and the potential impact of medical procedures on its manifestation in adolescents.
Area of Science:
- Vascular Surgery
- Pediatric Pathology
- Forensic Medicine
Background:
- Buerger's disease is a rare inflammatory condition affecting limb vasculature.
- Diagnosis and treatment strategies remain challenging for vascular surgeons globally.
- The etiology of Buerger's disease is largely unknown.
Purpose of the Study:
- To present a unique case of Buerger's disease in a pediatric patient.
- To explore diagnostic difficulties and treatment implications.
- To understand the role of routine medical interventions in disease manifestation.
Main Methods:
- Case report of a 15-year-old girl with suspected iatrogenic injury.
- Forensic histological examination of affected tissues.
- Retrospective analysis of comprehensive medical documentation.
Main Results:
- Initial misdiagnosis as iatrogenic pathology following aminazine injection.
- Correct diagnosis of Buerger's disease established via forensic examination.
- Identification of routine medical manipulation as a potential trigger for disease manifestation.
Conclusions:
- Buerger's disease can present with a larvated course, mimicking other conditions.
- Accurate diagnosis requires thorough investigation, including forensic analysis.
- Medical interventions may precipitate or exacerbate underlying Buerger's disease in susceptible individuals.
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