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JAK inhibitors in refractory dermatomyositis: A case series
L Corbella-Bagot1, X Bosch-Amate1, E Gimeno-Ribes1
1Department of Dermatology, Hospital Clínic de Barcelona, University of Barcelona, Barcelona, Catalunya, Spain.
Abstract:
This retrospective cohort study assessed the efficacy and safety of Janus kinase (JAK) inhibitors, tofacitinib and baricitinib, in 14 patients with refractory dermatomyositis (DM), a multisystemic autoimmune disorder with limited therapeutic options. Results demonstrated a significant median decrease of 21 points and a 76% reduction in the Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI) scores, along with a complete resolution of muscular symptoms in 64% of the patients. JAK inhibitors were effective in managing refractory DM across various subtypes with mild and manageable adverse events.
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