Related Experiment Video
Updated: Jun 23, 2025
Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
Published on: May 13, 2019
Peri-operative fever and LVAD: SIRS or impaired right ventricular strain?
Stefanie Marek-Iannucci1, Riley Wildemann2, Yevgeniy Brailovsky1
1Advanced Heart Failure and Transplant Cardiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
Background:
An inflammatory milieu after left ventricular assist device (LVAD) implantation is associated with multi-organ dysfunction and pre-operative heightened inflammatory state is associated with right ventricular failure after LVAD implantation.
Methods:
We performed a retrospective analysis of 30 LVAD patients in our institution within the last 2 years for the development of fever and compared them to 30 non-LVAD open-heart surgery patients.
Results:
Our results suggest that patients undergoing LVAD implantation are more likely to develop fever in the immediate post-operative period compared to other open-heart surgeries. This is independent of pharmacological treatment, age, or ethnical background. Females and obese patients were more likely to develop fever.
Conclusion:
Patients with right ventricular dysfunction, as demonstrated by elevated central venous pressure (CVP), had the strongest correlation with fever development. These results pose the question if there is a systemic inflammatory response-like phenomenon driven by increased right ventricular dysfunction.
